ISSN 1214-0287 (on-line), ISSN 1214-021X (printed)
J Appl Biomed
Volume 10 (2012), No 1, p 41-50
DOI 10.2478/v10136-011-0009-0

Jerte Valley cherry-based product modulates serum inflammatory markers in rats and ringdoves

Jonathan Delgado, Maria del Pilar Terron, Maria Garrido, Carmen Barriga, Javier Espino, Sergio Damian Paredes, Ana Beatriz Rodriguez

Address: Ana Beatriz Rodriguez, Department of Physiology, Neuroimmunophysiology and Chrononutrition Research Group, Faculty of Science, University of Extremadura Avda. de Elvas s/n, 06006, Badajoz, Spain
moratino@unex.es

Received 4th May 2011.
Revised 27th May 2011.
Published online 15th July 2011.

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SUMMARY
Ageing is commonly accompanied by a chronic subclinical inflammatory status that coexists with immune dysfunction. Consumption of foods rich in antioxidants is associated with a lower incidence of chronic diseases. The aim of this study was to evaluate the effect of the consumption of a Jerte Valley cherry-based beverage on the inflammatory load in two different animal species: rats and ringdoves (Streptopelia risoria); each divided into two age groups. To this purpose, circulating levels of both pro-inflammatory (IL-1beta and TNF-alpha) and anti-inflammatory (IL-4 and IL-2) cytokines were measured before and after a 10-day treatment with the Jerte Valley cherry-based beverage. Our results suggest that the 10-day treatment with the Jerte Valley cherry-based beverage modulated the balance of pro- and anti-inflammatory cytokines in both rats and ringdoves by down-regulating the levels of pro-inflammatory (IL-1beta and TNF-alpha) cytokines and up-regulating the levels of anti-inflammatory (IL-4 and IL-2) cytokines. Moreover, old animals showed imbalanced levels of inflammatory markers towards a pro-inflammatory status, thereby underlining the fact that ageing is usually accompanied by systemic inflammation and inflammation-related chronic diseases. In conclusion, since an increased dietary intake of vegetable-derived bioactive compounds may retard age-related immune dysfunctions and prolong life-span, supplementing diets with the cherry-based beverage may reduce the inflammatory load by modulating the serum concentrations of some markers of inflammation.

KEY WORDS
sweet cherry; inflammation; cytokine; melatonin; rat; ringdove

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