ISSN 1214-0287 (on-line), ISSN 1214-021X (printed)
J Appl Biomed
Volume 10 (2012), No 1, p 1-8
DOI 10.2478/v10136-012-0002-2

Fullerene nanoparticles and their anti-oxidative effects: a comparison to other radioprotective agents

Jirina Vavrova, Martina Rezacova, Jaroslav Pejchal

Address: Jirina Vavrova, Department of Radiobiology, University of Defence, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic
vavrova@pmfhk.cz

Received 17th August 2011.
Revised 31st October 2011.
Published online 2nd November 2011.

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SUMMARY
Radiation therapy occupies an important position in the treatment of malignant diseases in spite of the existence of radiation side effects on normal tissues. Thus, substances are being developed which are designed to reduce both the acute and long term radiation effects on healthy tissues. Currently a sulphur-containing compound amifostine (WR2721, ethyol) is used in clinical practice as a radioprotectant. However, it itself has considerable side effects including hypotension (found in 62% of patients), hypocalcaemia, diarrhoea, nausea, and vomiting. Carbon nanospheres, known as fullerenes, and their water soluble derivatives (e.g. C60(OH)24, dendrofullerene DF-1) exert anti-oxidative properties and reduce damage to the DNA in irradiated cells. Water soluble fullerenes are low-toxic substances and thus, are attractive in terms of their use as radioprotectants.

KEY WORDS
ionizing radiation; fullerenes; antioxidant; radioprotection; nanoparticles

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