ISSN 1214-0287 (on-line), ISSN 1214-021X (printed)
J Appl Biomed
Volume 10 (2012), No 2, p 109-117
DOI 10.2478/v10136-011-0016-1

A cherry nutraceutical modulates melatonin, serotonin, corticosterone, and total antioxidant capacity levels: effect on ageing and chronotype

Jonathan Delgado, Maria Pilar Terron, Maria Garrido, Jose Antonio Pariente, Carmen Barriga, Ana Beatriz Rodriguez, Sergio Damian Paredes

Address: Ana Beatriz Rodriguez Moratinos, Department of Physiology (Neuroimmunophysiology and Chrononutrition Research Group), Faculty of Science, University of Extremadura, Avda. de Elvas, s/n, 06006, Badajoz, Spain
moratino@unex.es

Received 20th July 2011.
Revised 5th September 2011.
Published online 31st October 2011.

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SUMMARY
Impaired daily rhythms in vertebrate physiology occur with age. Particularly, age-related changes in melatonin and serotonin rhythms and hypercortisolemia have been reported to be linked to age-related disorders. This study was aimed at assessing the effect of a Jerte Valley cherry-based nutraceutical product (patent no ES 2342141 B1), which contains high levels of tryptophan, serotonin, and melatonin, on the serum melatonin, serotonin, corticosterone, and total antioxidant capacity (TAC) levels in young and old ring doves (Streptopelia risoria) and rats (Rattus norvegicus) as representatives of animals with diurnal and nocturnal habits, respectively. The animals consumed the cherry product for 10 days. Serum melatonin, serotonin, corticosterone, and TAC were measured with commercial ELISA kits. The consumption of the cherry product induced a significant increase in the circulating levels of melatonin and serotonin, as well as in the serum TAC and a significant decrease in the circulating levels of corticosterone in both species and groups of age as compared to their respective values in the control groups. The consumption of a Jerte Valley cherry-based nutraceutical product may help to counteract the decrease in melatonin and serotonin and the increase in oxidative stress, suggesting a potential health benefit especially in aged populations where these parameters have been found to be altered.

KEY WORDS
cherry; corticosterone; melatonin; serotonin; total antioxidant capacity

REFERENCES
Berger J. A two-clock model of circadian timing in the immune system of mammals. Pathol Biol (Paris). 56: 286-291, 2008.
[CrossRef] [PubMed]

Boadle-Biber MC. Regulation of serotonin synthesis. Prog Biophys Mol Biol. 60: 1-15, 1993.
[CrossRef]

Bodnoff SR, Humphreys AG, Lehman JC, Diamond DM, Rose GM, Meaney MJ. Enduring effects of chronic corticosterone treatment on spatial learning, synaptic plasticity, and hippocampal neuropathology in young and mid-aged rats. J Neurosci. 15: 61-69, 1995.
[PubMed]

Bowman RE, Maclusky NJ, Diaz SE, Zrull MC, Luine VN. Aged rats: sex differences and responses to chronic stress. Brain Res. 1126: 156-166, 2006.
[CrossRef]

Cubero J, Toribio F, Garrido M, Hernandez MT, Maynar J, Barriga C, Rodriguez AB. Assays of the amino acid tryptophan in cherries by HPLC-fluorescence. Food Anal Methods. 3: 36-39, 2010.
[CrossRef]

Detanico BC, Piato AL, Freitas JJ, Lhullier FL, Hidalgo MP, Caumo W, Elisabetsky E. Antidepressant-like effects of melatonin in the mouse chronic mild stress model. Eur J Pharmacol. 607: 121-125, 2009.
[CrossRef] [PubMed]

Duncan MJ, Crafton CJ, Wheeler DL. Ageing regulates 5-HT(1B) receptors and serotonin reuptake sites in the SCN. Brain Res. 856: 213-219, 2000.
[CrossRef]

Esteban S, Nicolaus C, Garmundi A, Rial RV, Rodriguez AB, Ortega E, Ibars CB. Effect of orally administered L-tryptophan on serotonin, melatonin, and the innate immune response in the rat. Mol Cell Biochem. 267: 39-46, 2004.
[CrossRef] [PubMed]

Fernstrom JD, Wurtman RJ. Brain serotonin content: physiological dependence on plasma tryptophan levels. Science. 173: 149-152, 1971.
[CrossRef] [PubMed]

Garau C, Aparicio S, Ruben VR, Nicolau MC, Esteban S. Age-related changes in circadian rhythm of serotonin synthesis in ring doves: Effects of increased tryptophan ingestion. Exp Gerontol. 41: 40-48, 2006.
[CrossRef] [PubMed]

Garrido M, Espino J, Gonzalez-Gomez D, Lozano M, Cubero J, Toribio-Delgado AF, Maynar-Marino JI, Terrón MP, Munoz JL, Pariente JA, Barriga C, Paredes SD, Rodriguez AB. A nutraceutical product based on Jerte Valley cherries improves sleep and augments the antioxidant status in humans. e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism. 4: e321-e323, 2009.

Garrido M, Paredes SD, Cubero J, Lozano M, Toribio-Delgado AF, Munoz JL, Reiter RJ, Barriga C, Rodriguez AB. Jerte Valley cherry-enriched diets improve nocturnal rest and increase 6-sulfatoxymelatonin and total antioxidant capacity in the urine of middle-aged and elderly humans. J Gerontol A Biol Sci Med Sci. 65: 909-914, 2010a.
[CrossRef] [PubMed]

Garrido P, de Blas M, Del Arco A, Segovia G, Mora F. Aging increases basal but not stress-induced levels of corticosterone in the brain of the awake rat. Neurobiol Aging. 33: 375-382, 2010b.
[CrossRef] [PubMed]

Gitto E, Tan DX, Reiter RJ, Karbownik M, Manchester LC, Cuzzocrea S, Fulia F, Barberi I. Individual and synergistic antioxidative actions of melatonin: studies with vitamin E, vitamin C, glutathione and desferrioxamine (desferoxamine) in rat liver homogenates. J Pharm Pharmacol. 53: 1393-1401, 2001.
[CrossRef] [PubMed]

Gonzalez-Gomez D, Lozano M, Fernandez-Leon MF, Ayuso MC, Bernalte MJ, Rodriguez AB. Detection and quantification of melatonin and serotonin in eight sweet cherry cultivars (Prunus avium L.). Eur Food Res Technol. 229: 223-229, 2009.
[CrossRef]

Huether G, Poeggeler B, Adler L, Ruther E. Effects of indirectly acting 5-HT receptor agonists on circulating melatonin levels in rats. Eur J Pharmacol. 238: 249-254, 1993.
[CrossRef]

Kang SY, Seeram NP, Nair MG, Bourquin LD. Tart cherry anthocyanins inhibit tumor development in Apc(Min) mice and reduce proliferation of human colon cancer cells. Cancer Lett. 194: 13-19, 2003.
[CrossRef]

Kelley DS, Rasooly R, Jacob RA, Kader AA, Mackey BE. Consumption of Bing sweet cherries lowers circulating concentrations of inflammation markers in healthy men and women. J Nutr. 136: 981-986, 2006.
[PubMed]

Kim DO, Heo HJ, Kim YJ, Yang HS, Lee CY. Sweet and sour cherry phenolics and their protective effects on neuronal cells. J Agric Food Chem. 53: 9921-9927, 2005.
[CrossRef] [PubMed]

Mateos SS, Sanchez CL, Paredes SD, Barriga C, Rodriguez AB. Circadian levels of serotonin in plasma and brain after oral administration of tryptophan in rats. Basic Clin Pharmacol Toxicol. 104: 52-59, 2009.
[CrossRef]

Myers BL, Badia P. Changes in circadian rhythms and sleep quality with aging: mechanisms and interventions. Neurosci Biobehav Rev. 19: 553-571, 1995.
[CrossRef]

Nagata C, Nagao Y, Shibuya C, Kashiki Y, Shimizu H. Association of vegetable intake with urinary 6-sulfatoxymelatonin level. Cancer Epidemiol Biomarkers Prev. 14: 1333-1335, 2005.
[CrossRef]

Paredes SD, Reiter RJ. Melatonin: Helping cells cope with oxidative disaster. Cell Membr Free Radic Res. 2: 99-111, 2010.

Paredes SD, Terron MP, Cubero J, Valero V, Barriga C, Reiter RJ, Rodriguez AB. Comparative study of the activity/rest rhythms in young and old ringdove (Streptopelia risoria): correlation with serum levels of melatonin and serotonin. Chronobiol Int. 23: 779-793, 2006.
[CrossRef] [PubMed]

Paredes SD, Terron MP, Marchena AM, Barriga C, Pariente JA, Reiter RJ, Rodriguez AB. Effect of exogenous melatonin on viability, ingestion capacity, and free-radical scavenging in heterophils from young and old ringdoves (Streptopelia risoria). Mol Cell Biochem. 304: 305-314, 2007a.
[CrossRef] [PubMed]

Paredes SD, Barriga C, Rodriguez AB. Melatonin and tryptophan as therapeutic agents against the impairment of the sleep-wake cycle and immunosenescence due to aging in Streptopelia risoria. Neuro Endocrinol Lett. 28: 757-760, 2007b.
[PubMed]

Paredes SD, Terron MP, Valero V, Barriga C, Reiter RJ, Rodriguez AB. Orally administered melatonin improves nocturnal rest in young and old ringdoves (Streptopelia risoria). Basic Clin Pharmacol Toxicol. 100: 258-268, 2007c.
[CrossRef]

Paredes SD, Terron MP, Marchena AM, Barriga C, Pariente JA, Reiter RJ, Rodriguez AB. Tryptophan modulates cell viability, phagocytosis and oxidative metabolism in old ringdoves. Basic Clin Pharmacol Toxicol. 101: 56-62, 2007d.
[CrossRef]

Paredes SD, Terron MP, Cubero J, Valero V, Barriga C, Reiter RJ, Rodriguez AB. Tryptophan increases nocturnal rest and affects melatonin and serotonin serum levels in old ringdove. Physiol Behav. 90: 576-582, 2007e.
[CrossRef]

Paredes SD, Marchena AM, Bejarano I, Espino J, Barriga C, Rial RV, Reiter RJ, Rodriguez AB. Melatonin and tryptophan affect the activity-rest rhythm, core and peripheral temperatures, and interleukin levels in the ringdove: changes with age. J Gerontol A Biol Sci Med Sci. 64: 340-350, 2009a.
[CrossRef] [PubMed]

Paredes SD, Bejarano I, Terron MP, Barriga C, Reiter RJ, Rodriguez AB. Melatonin and tryptophan counteract lipid peroxidation and modulate superoxide dismutase activity in ringdove heterophils in vivo. Effect of antigen-induced activation and age. Age (Dordr). 31: 179-188, 2009b.
[CrossRef] [PubMed]

Paredes SD, Korkmaz A, Manchester LC, Tan DX, Reiter RJ. Phytomelatonin: a review. J Exp Bot. 60: 57-69, 2009c.
[CrossRef] [PubMed]

Reiter RJ, Tan DX, Mayo JC, Sainz RM, Lopez-Burillo S. Melatonin, longevity and health in the aged: an assessment. Free Radic Res. 36: 1323-1329, 2002.
[CrossRef] [PubMed]

Reiter RJ, Manchester LC, Tan DX. Melatonin in walnuts: influence on levels of melatonin and total antioxidant capacity of blood. Nutrition. 21: 920-924, 2005.
[CrossRef] [PubMed]

Reiter RJ, Paredes SD, Korkmaz A, Manchester LC, Tan DX. Melatonin in relation to the "strong" and "weak" versions of the free radical theory of aging. Adv Med Sci. 53: 119-129, 2008a.
[CrossRef] [PubMed]

Reiter RJ, Paredes SD, Korkmaz A, Jou MJ, Tan DX. Melatonin combats molecular terrorism at the mitochondrial level. Interdiscip Toxicol. 1: 137-149, 2008b.
[CrossRef] [PubMed]

Reiter RJ, Tan DX, Paredes SD, Fuentes-Broto L. Beneficial effects of melatonin in cardiovascular disease. Ann Med. 42: 276-285, 2010.
[CrossRef] [PubMed]

Rosier A, Dupont P, Peuskens J, Bormans G, Vandenberghe R, Maes M, de Groot T, Schiepers C, Verbruggen A, Mortelmans L. Visualisation of loss of 5-HT2A receptors with age in healthy volunteers using [18F]altanserin and positron emission tomographic imaging. Psychiatry Res. 68: 11-22, 1996.
[CrossRef]

Saito S, Tachibana T, Choi YH, Denbow DM, Furuse M. ICV melatonin reduces acute stress responses in neonatal chicks. Behav Brain Res. 165: 197-203, 2005.
[CrossRef] [PubMed]

Sanchez S, Paredes SD, Martin MI, Barriga C, Rodriguez AB. Effect of tryptophan administration on circulating levels of melatonin and phagocytic activity. J Appl Biomed. 2: 169-177, 2004.
[JAB]

Sanchez S, Paredes SD, Sanchez CL, Barriga C, Reiter RJ, Rodriguez AB. Tryptophan administration in rats enhances phagocytic function and reduces oxidative metabolism. Neuro Endocrinol Lett. 29: 1026-1032, 2008a.
[PubMed]

Sanchez S, Sanchez CL, Paredes SD, Rodriguez AB, Barriga C. The effect of tryptophan administration on the circadian rhythms of melatonin in plasma and the pineal gland of rats. J Appl Biomed. 6: 177-186, 2008b.
[JAB]

Terron MP, Cubero J, Marchena JM, Barriga C, Rodriguez AB. Melatonin and aging: in vitro effect of young and mature ring dove physiological concentrations of melatonin on the phagocytic function of heterophils from old ring dove. Exp Gerontol. 37: 421-426, 2002.
[CrossRef]

Terron MP, Paredes SD, Barriga C, Ortega E, Rodriguez AB. Comparative study of the heterophil phagocytic function in young and old ring doves (Streptopelia risoria) and its relationship with melatonin levels. J Comp Physiol B. 174: 421-427, 2004.
[CrossRef] [PubMed]

Terron MP, Paredes SD, Barriga C, Ortega E, Reiter RJ, Rodriguez AB. Melatonin, lipid peroxidation, and age in heterophils from the ring dove (Streptopelia risoria). Free Radic Res. 39: 613-619, 2005.
[CrossRef]
[PubMed]

Terron MP, Delgado J, Paredes SD, Barriga C, Reiter RJ, Rodriguez AB. Effect of melatonin and tryptophan on humoral immunity in young and old ringdoves (Streptopelia risoria). Exp Gerontol. 44: 653-658, 2009.
[CrossRef] [PubMed]

Van Cauter E, Leproult R, Plat L. Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men. JAMA. 284: 861-868, 2000.
[CrossRef]

Wang GJ, Volkow ND, Logan J, Fowler JS, Schlyer D, MacGregor RR, Hitzemann RJ, Gur RC, Wolf AP. Evaluation of age-related changes in serotonin 5-HT2 and dopamine D2 receptor availability in healthy human subjects. Life Sci. 56: PL249-253, 1995.
[CrossRef]

Zhdanova IV, Wurtman RJ, Regan MM, Taylor JA, Shi JP, Leclair OU. Melatonin treatment for age-related insomnia. J Clin Endocrinol Metab. 86: 4727-4730, 2001.
[CrossRef]

Zisapel N, Tarrasch R, Laudon M. The relationship between melatonin and cortisol rhythms: Clinical implications of melatonin therapy. Drug Dev Res. 65: 119-125, 2005.
[CrossRef]
CITED

Delgado J, Terron MP, Garrido M, Pariente JA, Barriga C, Rodriguez AB, Paredes SD. Diets enriched with a Jerte Valley cherry-based nutraceutical product reinforce nocturnal behaviour in young and old animals of nocturnal (Rattus norvegicus) and diurnal (Streptopelia risoria) chronotypes. J Anim Physiol Anim Nutr. 97: 137-145, 2013.

Berger J. Influence of food restriction on mammalian immunity. J Appl Biomed. 1: 1-5, 2013.

Espino J, Pariente JA, Rodriguez AB. Oxidative stress and immunosenescence: Therapeutic effects of melatonin. Oxid Med Cel Long. Art. no. 670294, 2012.

Delgado J, Del Pilar Terron M, Garrido M, Barriga C, Paredes SD, Espino J, Rodriguez AB. Systemic inflammatory load in young and old ringdoves is modulated by consumption of a Jerte Valley cherry-based product. J Medic Food. 15: 707-712, 2012.


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