ISSN 1214-0287 (on-line), ISSN 1214-021X (printed)
J Appl Biomed
Volume 10 (2012), No 3, p 119-136
DOI 10.2478/v10136-012-0008-9

Non-alcoholic steatohepatitis: an overview including treatments with herbals as alternative therapeutics

Menaka Chanu Thounaojam, Ravirajsinh Navalsinh Jadeja, Ranjisinh Vijaysinh Devkar, Ayalur Vadathala Ramachandran

Address: Ranjitsinh Vijaysinh Devkar, Division of Phytotherapeutics and Metabolic Endocrinology, Faculty of Science, The M. S. University of Baroda, Vadodara-390002, Gujarat, India
phyto_met@yahoo.com

Received 4th August 2011.
Revised 25th October 2011.
Published online 25th October 2011.

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SUMMARY
Non-alcoholic steatohepatitis (NASH), an under- recognized hepatic ailment with increasing prevalence, is fast emerging as the dark horse of hepatic related morbidity and mortality. Though introduced as a hepatic condition as early as 1980, detailed exploration of its causes, underlying mechanisms and therapeutics has largely remained an ignored or neglected field. Only recently, the focus of attention has gravitated towards an understanding of NASH as a pathological manifestation of significance and a search for possible therapeutic interventions. Treatment schedules as of now involve life style management and usage of anti-diabetic or anti-obesity drugs and antioxidants. In the present review, we have focused on the available treatment schedules including herbal agents, plant extracts, polyherbal formulations and isolated phytocompounds. We present here a review of the available literature on pre-clinical and clinical evaluations of herbals including our recent findings on two plant extracts which can be used in mitigating NASH. This review attempts to provide a comprehensive account of NASH and the future of therapeutics and remediation by herbal principles, an aspect of the urgent need to target this important medical condition that contributes to many cases of silent morbidity and mortality.

KEY WORDS
non-alcoholic steatohepatitis; herbal medicine; phytocompounds; polyherbal formulation

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