ISSN 1214-0287 (on-line), ISSN 1214-021X (printed)
J Appl Biomed
Volume 11 (2013) No 1, p 1-5
DOI 10.2478/v10136-012-0029-4

Influence of food restriction on mammalian immunity

Josef Berger

Address: Josef Berger, Department of Preclinical and Clinical Studies, Faculty of Health and Social Studies, University of South Bohemia, Ceske Budejovice, Czech Republic
berger@jcu.cz

Received 28th September 2012.
Revised 14th November 2012.
Published online 7th December 2012.

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SUMMARY
There is often an imbalance between the intake of n-6 and n-3 polyunsaturated fatty acids in patients with inflammatory and autoimmune diseases. Oxidative damage and the production of reactive oxygen species by various immune cells follow during the ageing process. Caloric restriction induces a transcriptional response of the genes known to inhibit oxidative stress, tumourigenesis, splicing mRNA and inflammation. On the other hand, calorie malnutrition causes the depression of many immune functions. The accessibility of nutritional factors seems to be an important cause of circannual rhythms. Lowered food intake as an adverse effect of chemotherapy may be why the immune system is altered. Nutrients influence several diseases including diabetes, obesity, inflammatory immune dysfunctions, and neuropathies as well as behavioural characteristics and life span.

KEY WORDS
oxidative damage; gene; circannual; adverse effect; diabetes; neuropathy; life span

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