Journal of APPLIED BIOMEDICINE
ISSN 1214-0287 (on-line)
ISSN 1214-021X (printed)

Volume 1 (2003), No 2, p 61-70




The chemistry, pharmacology, and toxicology of the biologically active constituents of the herb Hypericum perforatum L.

Jiri Patocka

Address: Jiri Patocka, Katedra toxikologie, Vojenska lekarska akademie, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic and Faculty of Health and Social Sciences, Ceske Budejovice, Czech Republic
patocka@pmfhk.cz

Received 3rd June 2002.
Published online 26th February 2003.

Full text article (pdf)

SUMMARY
St. John's wort (Hypericum perforatum) has been used as a medical herb for over 2000 years. Over the past two decades, its application as a standardized plant extract for treating depression has undergone rigorous scientific investigation, and its effectiveness has been shown in studies comparing it with other commonly used antidepressants and placebos. Safety and tolerability studies have revealed that Hypericum preparations have better safety and tolerability profiles than synthetic antidepressants. The indications for St. John's wort preparations are mild or moderate depression. The mechanism of the antidepressant action of Hypericum extract is not fully known. The view of the chemical composition and pharmaceutical a toxicological properties of biologically active substances of Hypericum perforatum is the main purpose of this paper.

KEY WORDS
Hypericum perforatum; antidepressant; pharmacology; toxicology


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