Journal of APPLIED BIOMEDICINE
ISSN 1214-0287 (on-line)
ISSN 1214-021X (printed)

Volume 1 (2003), No 3, p 161-168




Effects of genistein on insect haemocytes

Josef Berger, Sylvia Walczysko, Jitka Pavkova, Herwig O. Gutzeit

Address: Josef Berger, Department of Preclinical Studies, Faculty of Health and Social Care, South Bohemian University, Branisovska 31, 370 05 Ceske Budejovice, Czech Republic
berger@jcu.cz

Received 16th June 2003.
Published online 10th July 2003.

Full text article (pdf)

SUMMARY
We evaluate the possibility of using insects as a haematological biomodel and we test phytoestrogen isoflavanoid, genistein, in Schistocerca gregaria, Periplaneta americana and Dysdercus cingulatus. Various reactions of haemocytes were found in these three species, both stimulation and inhibition of haemocyte concentration. The observed data reflected well the possible effects of soy products described in published studies on human subjects and it seems that future studies on the sensitivity of insect haemocytes could lead to an alternative haematological biomodel.

KEY WORDS
alternative biomodel; haemocyte; genistein; pre-clinical prediction


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