Journal of APPLIED BIOMEDICINE
ISSN 1214-0287 (on-line)
ISSN 1214-021X (printed)

Volume 1 (2003), No 4, p 207-211




Reactivation of organophosphate inhibited acetylcholinesterase activity by alpha,omega-bis-(4-hydroxyiminomethylpyridinium)alkanes in vitro

Kamil Kuca, Jiri Patocka, Jiri Cabal

Address: Kamil Kuca, Purkyne Military Medical Academy, Department of Toxicology, 500 01 Hradec Kralove, Trebesska 1575, Czech Republic
kucakam@pmfhk.cz

Received 24th May 2003.
Revised 2nd September 2003.
Published online 29th September 2003.

Full text article (pdf)

SUMMARY
In this article, we have followed up the relationship between the ability to reactivate acetylcholinesterase inhibited by organophosphorus compounds and the length of linking chain between two 4-hydroxyiminomethylpyridinium rings of acetylcholinesterase reactivators. alpha,omega-bis(4-hydroxyiminomethylpyridinium) alkanes have been used as the tested acetylcholinesterase reactivators. These oximes differ in the number of methylene groups on the connecting chain. A three or four membered linking chain seems to be the ideal length for the satisfactory reactivation potency with the exception of reactivators of cyclosarin-inhibited acetylcholinesterase. In this case, the most efficacious acetylcholinesterase reactivator has one methylene group on the connecting chain.

KEY WORDS
acetylcholinesterase; organophosporus compounds; tabun; sarin; cyclosarin; VX


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