In this article, we have followed up the relationship between the ability to reactivate acetylcholinesterase inhibited by organophosphorus compounds and the length of linking chain between two 4-hydroxyiminomethylpyridinium rings of acetylcholinesterase reactivators. alpha,omega-bis(4-hydroxyiminomethylpyridinium) alkanes have been used as the tested acetylcholinesterase reactivators. These oximes differ in the number of methylene groups on the connecting chain. A three or four membered linking chain seems to be the ideal length for the satisfactory reactivation potency with the exception of reactivators of cyclosarin-inhibited acetylcholinesterase. In this case, the most efficacious acetylcholinesterase reactivator has one methylene group on the connecting chain.
acetylcholinesterase; organophosporus compounds; tabun; sarin; cyclosarin; VX
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