Absinthe is a flavoured distilled liquor, emerald green in colour, turning to cloudy, opalescent white when mixed with water. It has inspired many prominent artists, writers and poets - Vincent Van Gogh, Oscar Wilde, Pablo Picasso and Ernest Hemingway just to name a few. Absinthe was first produced commercially in 1797 by Henry-Louis Pernod, who purchased the formula from a French exile living in Switzerland. The wormwood, Artemisia absinthium, is the chief flavouring ingredient of absinthe and the presence of monoterpene thujone in this drug was the reason for the prohibition of the production and sale of absinthe in many countries. Thujone is a toxic chemical present in wormwood and is responsible for the pharmacological and toxicological properties of absinthe.
absinthe; thujone; composition; metabolites; detoxification
Arnold WN: Absinthe. Sci Amer 260:112-117, 1989.
Arnold WN: Vincent van Gogh and the thujone connection. JAMA 260:3042-3044, 1988.
Arnold WN: Vincent van Gogh: Chemicals, crises, and creativity Birkhauser; Berlin, Federal Republic of Germany, 1992.
Bonkovsky HL, Cable EE, Cable JW, Donohue SE, White EC, Greene YJ, Lambrecht RW, Srivastava KK, Arnold WN: Porphyrogenic properties of the terpenes camphor, pinene, and thujone (with a note on historic implications for absinthe and the illness of Vincent van Gogh). Biochem Pharmacol 43:2359-2368, 1992.
Browne RG, Weissman A: Discriminative stimulus properties of delta-9-tetrahydrocannabinol: mechanistic studies. J Clin Pharmacol 21:227-234, 1981.
Coats JR: Risks from natural versus synthetic insecticides. Annu Rev Entomol 39:489-515, 1994.
Cole LM, Casida JE: Pestic Biochem Physio. 44:1-8, 1992.
del Castillo J, Anderson M, Rubottom GM: Marijuana, absinthe and the central nervous system. Nature 253:365-366, 1975.
Duke JA: CRC handbook of medicinal herbs. Boca Raton, Florida: CRC Press, Inc., 1985.
Enna SJ, Bowery NG (eds.): The GABA Receptors, Humana, Totowa, 2nd Ed., 1997.
Gambelunghe C, Melai P: Absinthe: enjoying a new popolarity among young people? Forensic Sci Int 130:183-186, 2002.
Grainge M, Ahmed S: Handbook of Plants with Pest-Control Properties Wiley, New York, pp. 35-36, 1988.
Greenberg JH, Mellors A, McGowan JC: Molar volume relationships and the specific inhibition of a synaptosomal enzyme by psychoactive cannabinoids. J Med Chem 21:1208-1212, 1978.
Holstege CP, Baylor MR, Rusyniak DE: Absinthe: return of the Green Fairy. Neurol 22:89-93, 2002.
Hold KM, Sirisoma NS, Casida JE: Detoxification of alpha- and beta-Thujones (the active ingredients of absinthe): site specificity and species differences in cytochrome P450 oxidation in vitro and in vivo. Chem Res Toxicol 14:589-595, 2001.
Ishida T, Toyota M, Asakawa Y: Terpenoid biotransformation in mammals. V. Metabolism of (+)-citronellal, (+-)-7-hydroxycitronellal, citral, (-)-perillaldehyde, (-)-myrtenal, cuminaldehyde, thujone, and (+-)-carvone in rabbits. Xenobiotica 19:843-855, 1989.
Kulkami SK, Mehta AK, Ticku MK: Comparison of anticonvulsant effect of ethanol against NMDA-, kainic acid- and picrotoxin-induced convulsions in rats. Life Sci 46:481-487, 1990.
Lee S, Tsao R, Peterson C, Coats JR: Insecticidal activity of monoterpenoids to western corn rootworm (Coleoptera: Chrysomelidae), twospotted spider mite (Acari: Tetranychidae), and house fly (Diptera: Muscidae). J Econ Entomol 90:883-892, 1997.
Meschler J, Howlett AC: Thujone exhibits low affinity for cannabinoid receptors but fails to evoke cannabimimetic responses. Pharmacol Biochem Behav 62:473-480, 1999.
Matthews HB, Lucier GW, Fisher KD: Medicinal herbs in the United States: research needs. Environ Health Perspect 107:773-778, 1999.
Max B: This and that. TIPS 11:58-60, 1990.
Millet Y, Jouglard J, Steinmetz MD, Tognetti P, Joanny P, Arditti J: Toxicity of some essential plant oils. Clinical and experimental study. Clin Toxicol 8:1485-1498, 1981.
Morrant JC: The wing of madness: the illness of Vincent van Gogh. Can J Psychiat 38:480-484, 1993.
Ott J: Pharmacotheon. Natural Products Co., Kennewick, USA, 1993.
Pal DC, Jain SK: Notes on Lodha medicine in Midnapur District, West Bengal, India. Economic Botany 43:464-470, 1989.
Patocka J, Plucar B: Absint a jeho psychiatricka reflexe. Psychiatrie 7:96-99, 2003.
Pendell D: Pharmakopoeia. Mercury House, San Francisco, 1995.
Pinto-Scognamiglio W: Connaissances actuelles sur l'activite pharmacodynamique de la thuyone aromatisant naturel d'un emploi etendu [Current knowledge on the pharmacodynamic activity of the prolonged administration of thujone, a natural flavoring agent]. Boll Chimico Farmaceutico 106:292-300, 1967.
Ratra GS, Kamita SG, Casida JE: Role of human GABA(A) receptor beta3 subunit in insecticide toxicity. Toxicol Appl Pharmacol 172:233-240, 2001.
Rice KC, Wilson RS: (-)-3-Isothujone, a small nonnitrogenous molecule with antinociceptive activity in mice. J Med Chem 19:1054-1057, 1976.
Simon JE, Chadwick AF, Craker LE: Herbs: An Indexed Bibliography. 1971-1980. The Scientific Literature on Selected Herbs, and Aromatic and Medicinal Plants of the Temperate Zone. Archon Books, 770 pp., Hamden, USA, 1984.
Strang J, Arnold WN, Peters T: Absinthe: what's your poison? Though absinthe is intriguing, it is alcohol in general we should worry about. Brit Med J 319:1590-1592, 1999.
Vogt DD, Montagne M: Absinthe: behind the emerald mask. Int J Addict 17:1015-1029, 1982.
Montagne M. Drugs on the Internet, Part V: Absinthe, Return of the Emerald Mask. Substance Use Misuse. 48: 506-512, 2013.
Fasoli E, D'Amato A, Citterio A, Righetti PG. Anyone for an aperitif? Yes, but only a Braulio DOC with its certified proteome. J Proteomics. 75: 3374-3379, 2012.
Dawidowicz AL, Dybowski MP. Fast determination of alpha- and beta-thujone in alcoholic beverages using solid-phase extraction and gas chromatography. Food Control. 25: 197-201, 2012.
Radulovic NS, Blagojevic PD, Skropeta D, Zarubica AR, Zlatkovic BK, Palic RM. Misidentification of tansy, Tanacetum macrophyllum, as yarrow, Achillea grandifolia: a health risk or benefit? Nat Product Commun. 5: 121-127, 2010.
Rojht H, Mesko A, Vidrih M, Trdan S. Insecticidal activity of four different substances against larvae and adults of sycamore lace bug (Corythucha ciliata [Say], Heteroptera, Tingidae). [Insekticidno delovanje stirih snovi na licinke in odrasle osebke platanove cipkarke (Corythucha ciliata [Say], Heteroptera, Tingidae)]. Acta Agriculturae Slovenica. 93: 31-36, 2009.
Lopes-Lutz D, Mckay T, Kolodziejczyk PP. Distribution of volatiles in Artemisia cana. Pharm Biol. 46: 373-376, 2008.
Hajimehdipoor H, Zahedi H, Kalantari Khandani N, Abedi Z, Pirali-Hamedani M, Adib N. Investigation of alpha and beta-thujone content in common wormwood from Iran. J Med Plants. 7: 40-44+99, 2008.
Blagojevic P, Radulovic N, Palic R, Stojanovic G. Chemical composition of the essential oils of Serbian wild-growing Artemisia absinthium and Artemisia vulgaris. J Agric Food Chem. 54: 4780-4789, 2006.
Sajjadi S-E, Ghannadi A: Essential oil of the Persian sage, Salvia rhytidea Benth. Acta Pharm. 55: 321-326, 2005.
van Boxtel ChJ: Artemisia and Artemisinin, a story about toxicity. Uppsala Rep. 25: 1-4, 2004.