Journal of APPLIED BIOMEDICINE
ISSN 1214-0287 (on-line)
ISSN 1214-021X (printed)

Volume 2 (2004), No 2, p 95-100




Biomedical aspects of chiral molecules

Jiri Patocka, Ales Dvorak

Address: Jiri Patocka, Department of Toxicology, Military Medical Academy, Hradec Kralove and Faculty of Health and Social Studies, University of South Bohemia, Ceske Budejovice, Czech Republic
patocka@pmfhk.cz

Received 12th January 2004.
Revised 24th February 2004.
Published online 20th April 2004.

Full text article (pdf)

SUMMARY
This article defines some of the terms used in chiral chemistry and some of the basic mechanistic issues that arise in stereochemistry in pharmacology. Attention is also drawn to the impact of stereochemistry on drug regulation and its significance for new drug development. The stereoselectivity of drugs is underpinned by the fact that the human body is essentially a chiral structure. The rationale for development of chiral drugs is the suggestion that single stereoisomer drugs would provide superior therapy by allowing reductions in dosage, reduced variability in metabolism and response, simpler dose-response relationships and improved tolerability.

KEY WORDS
chiral drug; stereoisomer; enantiomer; stereochemistry; stereopharmacology


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