Journal of APPLIED BIOMEDICINE
ISSN 1214-0287 (on-line)
ISSN 1214-021X (printed)

Volume 2 (2004), No 3, p 123-130




Alzheimer's disease: neurobiological advances supporting proposals for new therapeutical approaches

Andre Nieoullon

Address: Andre Nieoullon, Cellular Interactions, Neurodegeneration and Neuroplasticity (IC2N) Research Unit UMR6186-CNRS, l'Universite de la Mediterranee, 31, Chemin Joseph Aiguier, 13402 Marseilles cedex 20, France
nieoullon@lncf.cnrs-mrs.fr

Received 21st April 2004.
Revised 6th May 2004.
Published online 4th June 2004.

Full text article (pdf)

SUMMARY
Alzheimer's disease is one of the most important diseases related to ageing. The social and human cost is very high especially because of the increase in the normal life span in developed countries. There is presently no cure for the disease and stimulating the cholinergic central neurotransmission is today the only therapeutic approach which has been shown to successfully improve the cognitive state in a significant population of patients. In such a context, research projects should be aimed specifically at reducing brain lesions resulting from the disease, especially those due to the amyloid peptide accumulation, and at reducing or even halting the clinical evolution of the disease and consequent neurodegenerative processes.

KEY WORDS
neuroprotection; amyloid protein precursor (APP); betaA4 protein; tau protein; astrocytes; excitatory amino acids


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