ISSN 1214-0287 (on-line)
ISSN 1214-021X (printed)

Volume 2 (2004), No 4, p 195-198

A general method for the quaternization of N,N-dimethyl benzylamines with long chain n-alkylbromides

Kamil Kuca, Milan Kivala, Vlastimil Dohnal

Address: Kamil Kuca, Department of Toxicology, Purkyne Military Medical Academy, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic

Received 12th August 2004.
Revised 5th October 2004.
Published online 14th October 2004.

Full text article (pdf)

Benzalkonium bromides (BAK) are an important class of cationic surfactants with both industrial and commercial uses. They are used as preservatives for ophthalmic, nasal and parenteral products and they are also used as a topical antiseptic and medical equipment disinfectant. In this work a universal method for the preparation of these compounds is described. Using quaternization of N,N-dimethylbenzylamines with long-chain n-alkylbromides we have prepared C8, C10, C12, C14, C16, C18 and C20 homologues of the benzalkonium bromides (BAK).

benzalkonium bromides; dimethylbenzylamines; n-alkylbromides; alkylating agent; quaternization

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