Journal of APPLIED BIOMEDICINE
ISSN 1214-0287 (on-line)
ISSN 1214-021X (printed)

Volume 3 (2005), No 2, p 83-90




Synthesis and activity of 4-(2',4'-difluorobiphenylyl)-2-methybutyric acid (deoxoflobufen) and its derivatives

Petr Bulej, Miroslav Kuchar, Vladimira Panajotova, Alexandr Jegorov

Address: Petr Bulej, IVAX Pharmaceuticals, Ostravska 29, 747 70 Opava, Czech Republic
Alexandr_Jegorov@ivax-cz.com

Received 3rd January 2005.
Revised 7th February 2005.
Published online 12th May 2005.

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SUMMARY
The series of 4-(2',4'-difluorobiphenylyl)-2-methylbutyric acid (deoxoflobufen, 1) and its four amides and two salts were prepared and tested for anti-inflammatory activity in rats and mice, using as models carrageenan-induced paw oedema, pleuritis, and arachidonic acid-induced ear inflammation, and on leucotriene B4 production in cells.

KEY WORDS
deoxoflobufen; derivatives; salts; anti-inflammatory activity


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