ISSN 1214-0287 (on-line)
ISSN 1214-021X (printed)

Volume 3 (2005), No 2, p 91-99

Oxime reactivation of acetylcholinesterase inhibited by toxic phosporus ester: in vitro kinetics and thermodynamics

Jiri Patocka, Jiri Cabal, Kamil Kuca, Daniel Jun

Address: Department of Toxicology, School of Military Health Sciences, University of Defense, Hradec Kralove, Czech Republic

Received 1st November 2006.
Revised 19th December 2006.
Published online 12th February 2007.

Full text article (pdf)

Owing to the threat of organophosphate exposures, not only to pesticides but also to nerve agents, it is very important to know the whole process of organophosphates-inhibited acetylcholinesterase (AChE, EC reactivation. Although current antidotes against organophosphorus intoxications consist also of prophylactics, AChE reactivators are still needed especially in the case of intoxications with high doses of organophosphates, for which prophylactic treatment is not effective. For this reason, new AChE reactivators are still being developed. Our work summarizes accurately the whole reactivation process, and offers some help for scientists who are interested in the area of AChE reactivation.

acetylcholinesterase; reactivation; nerve agents; kinetics; thermodynamics; oximes

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