ISSN 1214-0287 (on-line)
ISSN 1214-021X (printed)

Volume 3 (2005), No 4, p 187-191

The chemopreventive effect of diallyl disulphide on N-nitrosodiethylamine induced heptocarcinogenesis

Thamilarasan Manivasagam, Perumal Subramanian, Ganapathy Suthakar, Musthafa Mohamed Essa

Address: Perumal Subramanian, Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar - 608 002, Tamil Nadu, India

Received 29th September 2005.
Revised 6th October 2005.
Published online 20th November 2005.

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In the present study we have investigated the anticarcinogenic property of diallyl disulphide (DADS) on hepatic thiobarbituric acid reactive substances (TBARS) and antioxidants such as reduced glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase in control, N-nitrosodiethylamine and diallyl disulphide treated rats. The levels of TBARS and activities of SOD and catalase were decreased in NDEA treated rats whereas GSH and GPx tended to increase in carcinogenic rats. Oral administration of DADS (60mg/kg body wt) tends to normalize these variables in liver. This clearly indicates that DADS could possess chemopreventive effects by modulating the oxidantantioxidant status of the living system. However, the exact mechanism remains to be elucidated.

DADS; hepatocarcinogenesis; lipid peroxidation; antioxidants

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