Journal of APPLIED BIOMEDICINE
ISSN 1214-0287 (on-line)
ISSN 1214-021X (printed)

Volume 4 (2006), No 2, p 73-86




Chronobiology's progress. Part II, chronomics for an immediately applicable biomedicine

Franz Halberg, Germaine Cornelissen, George Katinas, Levan Tvildiani, Marina Gigolashvili, Ketevan Janashia, Tim Toba, Miguel Revilla, Philip Regal, Robert B. Sothern, Hans W. Wendt, Zhengrong Wang, Michal Zeman, Rita Jozsa, R. B. Singh, Gen Mitsutake, Sergei M. Chibisov, Jong Lee, Dan Holley, Othild Schwartzkopff, Patrick Delmore, Kuniaki Otsuka, Earl E. Bakken, Jerzy Czaplicki and the International BIOCOS Group

Address: Franz Halberg, Halberg Chronobiology Center, University of Minnesota, Mayo Mail Code 8609, 420 Delaware St. S. E., Minneapolis, MN 55455, USA
halbe001@umn.edu

Received 22nd December 2005.
Revised 21st February 2006.
Published online 10th March 2006.

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SUMMARY
Chronomic cardiovascular surveillance serves to recognise and treat any risk elevation as well as overt disease, and to ascertain whether treatment is effective and, if so, for how long treatment effects lasts, be it for lowering an increased risk and/or in surveilling the success or failure of treatment. A treatment-associated increase in circadian amplitude of blood pressure (BP) may induce iatrogenic overswinging, also dubbed CHAT (circadian hyper-amplitude-tension), in some patients, thereby increasing cardiovascular disease risk unknowingly to care provider and receiver.

KEY WORDS
chronobioethics; food restriction; blood pressure surveillance; CHAT; health care


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CITED

Watanabe Y, Halberg F, Otsuka K, Cornelissen G. Toward a personalized chronotherapy of high blood pressure and a circadian overswing. Clin Exp Hypertens. 35: 257-266, 2013.

Halberg F, Cornelissen G, Abahreh TM, Kino T, Schwartzkopff O. Cardiology in Al Ahsa, Saudi Arabia: A great oasis literally and figuratively. World Heart J. 4: 247-259, 2011.

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