Journal of APPLIED BIOMEDICINE
ISSN 1214-0287 (on-line)
ISSN 1214-021X (printed)

Volume 4 (2006), No 4, p 163-170




Jun: the master regulator in healthy and cancer cells

Petr Vanhara, Jan Smarda

Address: Jan Smarda, Laboratory of Cell Differentiation, Institute of Experimental Biology, Faculty of Science, Masaryk University, Kotlarska 2, 611 37 Brno, Czech Republic
smarda@sci.muni.cz

Received 25th September 2006.
Revised 5th October 2006.
Published online 1st December 2006.

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SUMMARY
Healthy cells strictly regulate gene transcription to control crucial cellular regulatory pathways. Members of the Jun protein family, c-Jun, JunB, and JunD are key subunits of the transcription factor AP-1 that controls transcription from various gene promoters. The genes targeted by Jun affect essential life processes, such as cell cycle progression, differentiation or programmed cell death. Therefore, the loss of proper Jun function is often associated with cancer. This review summarizes recent advances in understanding of function of the Jun proteins in healthy and cancer cells.

KEY WORDS
AP-1; Jun; cancer; apoptosis; cell cycle; differentiation


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CITED

Pazos E, Jimenez-Balsa A, Mascarenas JL, Vazquez ME. Sensing coiled-coil proteins through conformational modulation of energy transfer processes - selective detection of the oncogenic transcription factor c-Jun. Chem Sci. 2: 1984-1987, 2011.

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