Journal of APPLIED BIOMEDICINE
ISSN 1214-0287 (on-line)
ISSN 1214-021X (printed)

Volume 5 (2007), No 3, p 125-130




Phenylhydrazine haematotoxicity

Josef Berger

Address: Josef Berger, Faculty of Health and Social Studies, University of South Bohemia, Emy Destinove, 370 05 Ceske Budejovice, Czech Republic
berger@zsf.jcu.cz

Received 16th May 2007.
Revised 29th June 2007.
Published online 6th August 2007.

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SUMMARY
Phenylhydrazine (PHZ) and its derivatives were first given a medical application at the end of the 19th century but with very little benefit. However, this compound seems to be very useful in models studying mechanisms of haemolytic anaemia. Phenylhydrazine induces a reactive oxygen species formation, peroxidation of lipids and oxidative degradation of spectrin in the membrane skeleton. PHZ-induced haemolytic injury seems to be derived from oxidative alternations to red blood cell proteins. This compound can modulate immune reactions.

KEY WORDS
reactive oxygen species; membrane proteins; spectrin; haemolytic anaemia; mutagenity


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