ISSN 1214-0287 (on-line)
ISSN 1214-021X (printed)

Volume 5 (2007), No 4, p 171-178

The antimutagenic and cytoprotective effects of amifostine: the role of p53

Diana Grochova, Jana Smardova

Address: Jana Smardova, Laboratory of Molecular Pathology, Department of Pathology, University Hospital Brno, Jihlavska 20, 625 00 Brno, Czech Republic

Received 7th September 2007.
Published online 26th October 2007.

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Radiotherapy and chemotherapy are the basic approaches in cancer treatment, but these procedures are often associated with a number of undesirable side effects worsening the quality of life of the patient. In recent years a number of protective compounds capable of reducing or eliminating these side effects have been extensively investigated (for example: dexrazoxan, mesna, glutathion or N-acetylcystein). One of these compounds is amifostine (WR-2721), a broad-spectrum cytoprotective drug, selectively protecting normal tissues from the toxic effects of therapy, while the malignant tissues are subject to the anti-tumour effects of the treatment. In addition, several studies have revealed certain antimutagenic activities of amifostine making this agent potentially useful in the prevention of therapy-induced secondary malignancies. This article summarizes the information available on the antimutagenic and cytoprotective effects of amifostine and its effects also on the activity of the p53 tumour suppressor.

amifostine; tumour suppressor p53; cytoprotective and antimutagenic compounds; WR-2721; WR-1065

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