Journal of APPLIED BIOMEDICINE
ISSN 1214-0287 (on-line)
ISSN 1214-021X (printed)

Volume 6 (2008), No 2, p 47-56




Genetically altered mice, man and medicine

Nirmala Bhogal

Address: Nirmala Bhogal, FRAME, Russell and Burch House, 96-98 North Sherwood Street, Nottingham NG1 4EE, UK
nirmala@frame.org.uk

Received 6th February 2008.
Revised 10th March 2008.
Published online 12th March 2008.

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SUMMARY
Several million genetically altered mice are used worldwide each year for research, toxicity testing, or simply to create or sustain mutant models. In fact, as our understanding of the genetic differences between mice and men improves, so does the drive to create mouse models of human disease and toxicity. However, while some models have proven to be useful and confer tangible benefits in terms of clinical management of disease, many others add little value to clinical medicine or human safety emphasising the need for a thorough investigation of the actual or future value of such models to human medicine.

KEY WORDS
disease; genetically altered; mouse; mutant; welfare


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