Journal of APPLIED BIOMEDICINE
ISSN 1214-0287 (on-line)
ISSN 1214-021X (printed)

Volume 6 (2008), No 3, p 117-129




Silver or silver nanoparticles: a hazardous threat to the environment and human health?

Nagender Reddy Panyala, Eladia M. Pena-Mendez, Josef Havel

Address: Josef Havel, Department of Chemistry, Faculty of Science, Masaryk University, Kotlarska 2, 61137 Brno, Czech Republic
havel@chemi.muni.cz

Received 12th April 2008.
Revised 27th May 2008.
Published online 23rd June 2008.

Full text article (pdf)

SUMMARY
These nanomaterials are already having an impact on health care. Now-a-days we are using nanoproducts in various fields. Of these, silver nanoparticles are playing a major role in the field of nanotechnology and nanomedicine.
Their unique size-dependent properties make these materials superior and indispensable as they show unusual physical, chemical and biological properties. Silver nanoparticles have potential antimicrobial activity towards many pathogenic microbes. Along with this antimicrobial activity, silver nanoparticles are showing unacceptable toxic effects on human health and the environment. The chronic exposure to silver causes adverse effects such as permanent bluish-grey discoloration of the skin (argyria) and eyes (argyrosis). Besides argyria and argyrosis, exposure to soluble silver compounds may produce other toxic effects like liver and kidney damage, irritation of the eyes, skin, respiratory and intestinal tract and changes to blood cells. This review summarizes the hazardous effects of silver nanoparticles in the environment and theirs toxic effects on human health.

KEY WORDS
silver nanoparticles; antimicrobial activity; argyria; argyrosis; silver toxicity

REFERENCES
Aaseth J, Olsen A, Halse J, Hovig T: Argyria-tissue deposition of silver as selenide. Scand J Clin Lab Invest 41:247-251, 1981.
[CrossRef] [PubMed]

Albright LJ, Wilson EM: Sub-lethal effects of several metallic salt-organic compounds combinations upon heterotrophic microflora of a natural water. Water Res 8:101-105, 1974.
[CrossRef]

Alt V, Bechert T, Steinrucke P, Wagener M, Seidel P, Dingeldein E, Domann E, Schnettler R: An in vitro assessment of the antibacterial properties and cytotoxicity of nanoparticulate silver bone cement. Biomaterials 25:4383-4391, 2004.
[CrossRef] [PubMed]

Armitage SA, White MA, Wilson HK: The determination of silver in whole blood and its application to biological monitoring of occupationally exposed groups. Ann Occup Hyg 40:331-338, 1996.
[PubMed]

Baldi C, Minoia C, Di Nucci A, Capodaglio E, Manzo L: Effects of silver in isolated rat hepatocytes. Toxicol Lett 41:261-269, 1988.
[CrossRef]

Bianchi L, Orlandi A, Di Stefani A, Ricci R, Chimenti S: "Familial" generalized argyria. Arch Dermatol 142:789-90, 2006.
[CrossRef] [PubMed]

Bogle KA, Dhole SD, Bhoraskar VN: Silver nanoparticles: synthesis and size control by electron irradiation. Nanotechnology 17:3204-3208, 2006.
[CrossRef]

Boosalis MG, McCall JT, Ahrenhalz DH, Solem LH, McClain CJ: Serum and urinary silver levels in thermal injury patients. Surgery 101:40-43, 1987.
[PubMed]

Borm PJ and Kreyling WJ: Toxicological hazards of inhaled nanoparticles-potential implications for drug delivery. J Nanosci Nanotechno. 4:521-551, 2004.
[CrossRef] [PubMed]

Bouts BA: Images in clinical medicine. Argyria. N Engl J Med 340:1554, 1999.
[CrossRef] [PubMed]

Brandt D, Park B, Hoang M, Jacobe HT: Argyria: secondary to ingestion of homemade silver solution. J Am Acad Dermatol 53:S105-S107, 2005.
[CrossRef] [PubMed]

Braydich-Stolle L, Hussain S, Schlager JJ, Hofmann MC: In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. Toxicol Sci 88:412-419, 2005.
[CrossRef] [PubMed]

Breitstadt R: Occupational exposure limits for metallic silver. In Proceedings of the 2nd European Precious Metals Conference, Lisbon, Portugal. 1995, 1-13pp.

Brooks SM: Lung disorders resulting from the inhalation of metals. Clin Chest Med 2:235-254, 1981.
[PubMed]

Buckley WR, Oster CF, Fasset DW: Localized argyria II. Chemical nature of the silver containing particles. Arch Dematol 92:697-705, 1965.
[CrossRef] [PubMed]

Burd A, Kwok CH, Hung SC, Chan HS, Gu H, Lam WK, Huang L: A comparative study of the cytotoxicity of silver-based dressings in monolayer cell, tissue explant, and animal models. Wound Rep Reg 15:94-104, 2007.
[CrossRef] [PubMed]

Catsakis LH, Sulica VI: Allergy to silver amalgams. Oral Surg 46:371-5, 1978.
[CrossRef]

Chang ALS, Khosravi V, Egbert B: A case of argyria after colloidal silver ingestion. J Cutaneous Pathol 33:809-811, 2006.
[CrossRef] [PubMed]

Chen X, Schluesener HJ: Nanosilver: A nanoproduct in medical application. Toxicol Lett 176:1-12, 2007.
[CrossRef] [PubMed]

Cheng D, Yang J, Zhao Y: Antibacterial materials of silver nanoparticles application in medical appliances and appliances for daily use. Chin Med Equip J 4:26-32, 2004.

Dietl HW, Anzil AP, Mehraein P: Brain involvement in generalized argyria. Clin Neuropath 3:32-38, 1984.
[PubMed]

Drake PL, Hazelwood KJ: Exposure-related health effects of silver and silver compounds: A Review. Ann Occup Hyg 49:575-585, 2005.
[CrossRef] [PubMed]

Eisler R: A review of silver hazards to plants and animals. In Andren AW, Bober TW. (eds.): Proc. 4th Int. Conf. Transport, Fate and Effects of Silver in the Environment, Madison, Wisconsin 1996, pp. 143-144 pp.

Elechiguerra JL, Burt JL, Morones JR, Camacho-Bragado A, Gao X, Lara HH, Yacaman MJ: Interaction of silver nanoparticles with HIV-1. J Nanobiotechnology 3: art. No. 6, 2005.

Espinal ML, Ferrando L, Jimenex DF: Asymptomatic blue nevus-like macule. Diagnosis: localized argyria. Arch Dermatol 132:461-4, 1996.

Fisher NM, Marsh E, Lazova R: Scar-localized argyria secondary to silver sulfadiazine cream. J Am Acad Dermatol 49:730-732, 2003.
[CrossRef]

Flegal AR, Davis JA, Connor MS, Conaway CH: Sources, transport, fate, and toxicity of pollutants in the San Francisco Bay estuary. J EnvironResearch 105:0-4, 2007.

Fung MC, Bowen DL: Silver products for medical indications: risk-benefit assessment. J Toxicol Clin Toxicol 34:119-126, 1996.
[CrossRef] [PubMed]

Furchner JE, Richmond CR, Drake GA: Comparative metabolism of radionuclides in mammals-IV. Retention of silver-110m in the mouse, rat, monkey and dog. Health Phys 15:505-14, 1968.
[CrossRef] [PubMed]

Gopinath P, Gogoi SK, Chattopadhyay A, Gosh SS: Implications of silver nanoparticle induced cell apoptosis for in vitro gene therapy. J Nanotechnol 19: art. No. 075104, 2008, 10pp.

Graham SA, O'Meara JM: The feasibility of measuring silver concentrations in vivo with x-ray fluorescence. Phys Med Biol 49:N259-266, 2004. Greene RM, Su WPD: Argyria. Am. Family Phys. 36:151-154, 1987.

Greene RM, Su WPD: Argyria. Am Fam Physician 36:151-154, 1987.

Gulbranson SH, Hud JA, Hansen RC: Argyria following the use of dietary supplements containing colloidal silver protein. Cutis 66:373-376, 2000.
[PubMed]

Hill WR, Pillsbury DM. Argyria: The pharmacology of silver. Baltimore, MD:Williams & Wilkins Company,1939.

Hogstrand C, Wood CM. In: The toxicity of silver to marine fish. In Andren AW, Bober TW (eds.): Proc. 4th Int. Conf. Transport, Fate and Effects of Silver in the Environment, Madison, Wisconsin 1996, pp. 109-112 pp.

Hussain SM, Hess KL, Gearhart JM, Geiss KT, Schlager JJ: In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicol in Vitro 19:975-983, 2005.
[CrossRef] [PubMed]

Hussain SM, Javorina MK, Schrand AM, Duhart HM, Ali SF, Schlager JJ: The interaction of manganese nanoparticles with PC-12 cells induces dopamine depletion. Toxicol Sci 92:456-463, 2006.
[CrossRef] [PubMed]

Johnston AM, Memon AA: A Medical Mystery. N Engl J Med 340:1011, 1999.
[CrossRef]

Jose RM, Jose LE, Alejandra C, Katherine H, Juan BK, JoseTR, Miguel JY: The bactericidal effect of silver nanoparticles. Nanotechnology 16:2346-2353, 2005.
[CrossRef] [PubMed]

Kaewamatawong T. Shimada A, Okajima A: Acute and Subacute Pulmonary Toxicity of Low Dose of Ultrafine Colloidal Silica Particles in Mice after Intratracheal Instillation. Toxicol Pathol 34:958-965, 2006.
[CrossRef] [PubMed]

Kone BC, Kaleta M, Gullans SR: Silver ion (Ag+)-Induced increases in cell membrane K+ and Na+ permeability in the renal proximal tubule: Reversal by thiol reagents. J Membr Biol 102:11-19, 1988.
[CrossRef] [PubMed]

Lee SM, Lee SH: Generalized argyria after habitual use of AgNO3. J Dermatol 21:50-53, 1994.
[PubMed]

Legat FJ, Goessler W, Schlagenhaufen C, Soyer HP: Argyria after short-contact acupuncture. Lancet 352(9123):241, 1998.
[CrossRef]

Limbach LK, Wick P, Manser P, Grass RN, Bruinink A, Stark WJ: Exposure of Engineered Nanoparticles to Human Lung Epithelial Cells: Influence of Chemical Composition and Catalytic Activity on Oxidative Stress. Environ Sci Technol 41:4158-4163, 2007.
[CrossRef]

Lippmann M, Yeates DB, Albert RE: Deposition, retention, and clearance of inhaled particles. Br J Ind.Med 37:337-362, 1980.
[PubMed]

Loeffler KU, Lee WR: Argyrosis of the lacrimal sac. Graefe’s Arch Clin Exp Ophthalmol 225:146-150, 1987.
[CrossRef]

Lok CN, Ho CM, Chen R, He QY, Yu WY, Sun H, Tam PK, Chiu JF, Che CM: Proteomic analysis of the mode of antibacterial action of silver nanoparticles. J Proteome Res 5:916-924, 2006.
[CrossRef] [PubMed]

Margaret IP, Lui SL, Poon VKM, Lung I, Burd A: Antimicrobial activities of silver dressings: an in vitro comparison. J Med Microbiol 55:59-63, 2006.
[CrossRef] [PubMed]

Marshall JP II, Schneider RP: Systemic argyria secondary to topical silver nitrate. Arch Dermatol 113:1077-1079, 1977.
[CrossRef] [PubMed]

McAuliffe ME, Perry MJ: Are nanoparticles potential male reproductive toxicants? A literature review. Nanotoxicology 1:204-210, 2007.
[CrossRef]

Menaguale G, Fazio R, Fazio M: Argyria: a case following the prolonged use of a rhinologic drug. Esper Dermatol (Roma) 4:299-303, 2003.

Morones JR, Elechiguerra JL, Camacho A, Holt K, Kouri JB, Ramirez JT, Yacaman MJ: The bactericidal effect of silver nanoparticles. J Nanotechnol 16:2346-2353, 2005.
[CrossRef] [PubMed]

Murata T, Kanao-koshikawa M, Takamatsu T: Effects of Pb, Cu, Sb, In and Ag contamination on the proliferation of soil bacterial colonies, soil dehydrogenase activity, and phospholipid fatty acid profiles of soil microbial communities. Water, Air & soil pollution 164:103-118, 2005.
[CrossRef]

Nordberg G, Gerhardsson LS: Silver. In Seiler HG, Sigel H, Sigel A (eds.): Handbook on Toxicity of Inorganic Compounds. Marcell Dekker, New York 1988, pp. 619-624 pp.

Ogden JS, Bogdanchikova NE, Corker JM and Petranovskii VP: Structure of silver clusters embedded in erionite channels. Eur Phys J D 9:605-608, 1999.
[CrossRef]

Padlewska K, Schwartz R: Argyria. In Kchan S, Vinson RP, Miller JJ, Gelfand, James, WD, Gross PR (eds): eMedicine: Dermatology and Online Medical Reference 2007. eMedicine.com, Inc., Omaha, NE 2007. (http://www.emedicine.com/)

Pariser RJ: Generalized argyria. Clinicopathologic features and histochemical studies. Arch Dermatol 114:373-380, 1978.
[CrossRef] [PubMed]

Phalen RF, Morrow PE: Experimental inhalation of metallic silver. Health Phys 24:509-518, 1973.
[CrossRef] [PubMed]

Prescott RJ, Wells S: Systemic argyria. J Clin Pathol 47:556-557, 1994.
[CrossRef] [PubMed]

Pyatenko A, Shimokawa K, Yamaguchi M: Synthesis of silver nanoparticles by laser ablation in pure water. J Appl Phys A: Mater Sci Proces A79:803-806, 2004.

Robinson-Bostom L, Pomerantz D, Wilkel C, Mader R, Lerner L, Dufresne R, Flotte T: Localized argyria with pseudo-ochronosis. J Am Acad Dermatol 46:222-229, 2002.
[CrossRef] [PubMed]

Rongioletti F, Robert E, Buffa P, Bertagno R, Rebora A: Blue nevi-like dotted occupational argyria. J Am Acad Dermatol 27:1015-1016, 1992.
[CrossRef]

Rosenman KD, Seixas N, Jacobs I: Potential nephrotoxic effects of exposure to silver. Br J Ind Med 44:267-272, 1987.
[PubMed]

Rosenman KD, Moss A, Kon S: Argyria: clinical implications of exposure to silver nitrate and silver oxide. J Occup Med 21:430-435, 1979.
[PubMed]

Rungby J, Danscher G: Localization of exogenous silver in brain and spinal cord of silver exposed rats. Acta Neuropathol 60:91-98, 1983a.
[CrossRef] [PubMed]

Rungby J, Danscher G: Neuronal accumulation of silver in brains of progeny from argyric rats. Acta Neuropathol 61:258-262, 1983b.
[CrossRef] [PubMed]

Saint S, Veenstra DL, Sullivan SD, Chenoweth C, Fendrick AM: The potential clinical and economic benefits of silver alloy urinary catheters in preventing urinary tract infection. Arch Intern Med 160:2670-2675, 2000.
[CrossRef] [PubMed]

Samuel U, Guggenbichler JP: Prevention of catheter-related infections: the potential of a new nano-silver impregnated catheter. Int J Antimicrob Agents 23S1:S75-S78, 2004.

Sarkar S, Jana AD, Samanta SK, Mostafa G: Facile synthesis of silver nano particles with highly efficient anti-microbial property. Polyhedron 26:4419-4426, 2007.
[CrossRef]

Sato S, Sueki H, Nishijima A: Two unusual cases of argyria: the application of an improved tissue processing method for X-ray microanalysis of selenium and sulphur in silver-laden granules. Br J Dermatol 140:158-163, 1999.
[CrossRef] [PubMed]

Scott KG, Hamilton JG: The metabolism of silver in the rat with radiosilver used as an indicator. Publ Pharmacol 2:241-262, 1950.

Senjen R: Nano silver - a threat to soil, water and human health? Friends of the Earth Australia March 2007. Available at: http://nano.foe.org.au/node/189
[CrossRef]

Sergeev MB, Kasaikin AV, Litmanovich AE: Cryochemical synthesis and properties of silver nanoparticle dispersions stabilised by poly(2-dimethylaminoethyl methacrylate). Mendeleev Commun 9:130-132, 1999.
[CrossRef]

Seung-heon S, Mi-kyung Y, Jeung-kyu K: The effects of nano-silver on the proliferation and cytokine production in peripheral blood mononuclear cells. Jpn J Rhinol 45:269, 2006.

Sharma CS, Sarkar S, Periyakaruppan A, Barr J, Wise K, Thomas R, Wilson BL, Ramesh GT: Single-walled carbon nanotubes induces oxidative stress in rat lung epithelial cells. J Nanosci Nanotechnol 7:2466-2472, 2007.
[CrossRef] [PubMed]

Shelley WB, Shelley ED, Burmeister V: Argyria: the intradermal "photograph", a manifestation of passive photosensitivity. J Am Acad Dermatol 16: 211-217, 1987.
[CrossRef]

Shin SH, Ye MK, Kim HS, Kang HS: The effects of nano-silver on the proliferation and cytokine expression by peripheral blood mononuclear cells. Int Immunopharmacol 7:1813-1821, 2007.
[CrossRef] [PubMed]

Soto KF, Carrasco A, Powell TG, Garza KM, Murr Le: Comparative in vitro cytotoxicity assessment of some manufactured nanoparticulate materials characterized by transmission electron microscopy. J Nanoparticle Res 7:145-169, 2005.
[CrossRef]

Soto KF, Murr LE, Garza KM: Cytotoxic Responses and Potential Respiratory Health Effects of Carbon and Carbonaceous Nanoparticulates in the Paso del Norte Airshed Environment. Int J Environ Res Public Health 5:12-25, 2008.
[CrossRef] [PubMed]

Staudt C, Heinrich R,Wucher A: Formation of large clusters during sputtering of silver. Nucl Istr And Meth In Phys Res B: 164-165, 677-686, 2000.
[CrossRef]

Sue YM, Lee JY, Wang MC, Lin TK, Sung JM, Huang JJ: Generalized argyria in two chronic hemodialysis patients. Am J Kidney Dis 37:1048-1051, 2001.
[CrossRef]

Sun Y, Xia Y: Shape controlled synthesis of gold and silver nanoparticles. Science 298:2176-2179, 2002.
[CrossRef] [PubMed]

Takenaka S, Karg E, Roth C, Schulz H, Ziesenis A, Heinzmann U, Schramel P, Heyder J: Pulmonary and systemic distribution of inhaled ultra fine silver particles in rats. Environ Health Perspect 4:547-551, 2001.

Throback IN, Johansson M, Rosenquist M, Pell M, Hansson M, Hallin S: Silver (Ag+) reduces denitrification and induces enrichment of novel nirK genotypes in soil. FEMS Microbiol Lett 270:189-194, 2007.
[CrossRef] [PubMed]

Tomi NS, Kranke B, Aberer W: A silver man. Lancet 363:532, 2004.
[CrossRef]

Venugopal B, Luckey TD (eds.): Metal toxicity in mammals. In Chemical toxicology of metals and metalloids. Academic Press, New York 1978, pp. 32-36.

Watanabe K: Histopathological study of damage to periodontal tissues by silver alloy metals in rats. J Jpn Assoc Periodontal 31:1021-1046, 1989.
[CrossRef]

Wen HC, Lin YN, Jian SR, Tseng SC, Weng MX, Liu YP, Lee PT, Chen PY, Hsu RQ, Wu WF, Chou CP: Observation of Growth of Human Fibroblasts on Silver Nanoparticles. J Phys Conf Ser 61:445-449, 2007.
[CrossRef]

Westhofen M, Schafer H: Generalized argyrosis in man: neurotological, ultrastructural and X-ray microanalytical findings. Arch Otorhinolaryngol 243:260-264, 1986.
[CrossRef] [PubMed]

White JML, Powell AM, Brady K, Russell-Jones R: Severe generalized argyria secondary to ingestion of colloidal silver protein. Clin Exp Dermatol 28:254-256, 2003.
[CrossRef] [PubMed]

Williams N, Gardner I: Absence of symptoms in silver refiners with raised blood silver levels. Occup Med 45:205-213, 1995.
[CrossRef] [PubMed]

Wood CM, Playle RC, Hogstrand C: Physiology and modelling of mechanisms of silver uptake and toxicity in fish. Environ Toxicol Chem 18:71-83, 1999.
[CrossRef]

Xia T, Kovochich M, Brant J, Hotze M, Sempf J, Oberley T, Sioutas C, Yeh JI, Wiesner MR, Nel AE: Comparision of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett 8:1794-1807, 2006.
[CrossRef] [PubMed]

Zhang Y, Sun J: A Study on the bio-safety for nano-silver as anti-bacterial materials. Chin J Med Instrumen 31:35-38, 2007b.

Zhang Y, Chen F, Zhuang J: Synthesis of silver nanoparticles via electrochemical reduction on compact zeolite film modified electrodes. Chem Commun (Camb.) 7:2814-2815, 2002.
[CrossRef] [PubMed]
CITED

Yang Y, Wang J, Xiu Z, Alvarez PJJ. Impacts of silver nanoparticles on cellular and transcriptional activity of nitrogen-cycling bacteria. Environ Toxicol Chem. 32: 1488-1494, 2013.

Levard C, Mitra S, Yang T, Jew AD, Badireddy AR, Lowry GV, Brown GE. Effect of chloride on the dissolution rate of silver nanoparticles and toxicity to E. coli. Environ Sci Technol. 47: 5738-5745, 2013.

Imani Fooladi AA, Hosseini HM, Hafezi F, Hosseinnejad F, Nourani MR. Sol-gel-derived bioactive glass containing SiO2-MgO-CaO-P 2O5 as an antibacterial scaffold. J Biomed Mater Res Part A. 101: 1582-1587, 2013.

Pattabi RM, Pattabi M. Antibacterial applications of silver nanoparticles. Mater Sci Forum. 7: 131-142, 2013.

Mahna N, Vahed SZ, Khani S. Plant In vitro culture goes nano: Nanosilver-mediated decontamination of Ex vitro explants. J Nanomedic Nanotechnol. 4: 3, 2013.

Barua S, Konwarh R, Bhattacharya SS, Das P, Devi KSP, Maiti TK, Mandal M, Karak N. Non-hazardous anticancerous and antibacterial colloidal 'green' silver nanoparticles. Coll Surf B. 105: 37-42, 2013.

Shirwaiker RA, Samberg ME, Cohen PH, Wysk RA, Monteiro-Riviere NA. Nanomaterials and synergistic low-intensity direct current (LIDC) stimulation technology for orthopedic implantable medical devices. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 5: 191-204, 2013.

Shams G, Ranjbar M, Amiri A. Effect of silver nanoparticles on concentration of silver heavy element and growth indexes in cucumber (Cucumis sativus L. negeen). J Nanopart Res. 15, art. no. 1630, 2013.

Massoud AA, Langer V, Gohar YM, Abu-Youssef MAM, Janis J, Lindberg G, Hansson K, Ohrstrom L. Effects of different substituents on the crystal structures and antimicrobial activities of six Ag(I) quinoline compounds. Inorg Chem. 52: 4046-4060, 2013.

Urbanova I, Husakova L, Sramkova J. Direct electrothermal atomic spectrometric determination of Ag in aqua regia extracts of soils, sediments, and sewage sludge with matrix modification. Environ Monit Assess. 185: 3327-3337, 2013.

Kharissova OV, Dias HVR, Kharisov BI, Perez BO, Perez VMJ. The greener synthesis of nanoparticles. Trends Biotechnol. 31: 240-248, 2013.

Negi H, Saravanan PR, Agarwal T, Haider Zaidi MG, Goel R. In vitro assessment of Ag2O nanoparticles toxicity against gram-positive and gram-negative bacteria. J General Appl Microbiol. 59: 83-88, 2013.

Lee C-J, Lee S, Jhon MS, Shin J. Factors influencing nanotechnology commercialization: An empirical analysis of nanotechnology firms in South Korea. J Nanopart Res. 15, art. no. 1444, 2013.

Esteban-Tejeda L, Da Silva AC, Mello-Castanho SR, Pacharroman C, Moya JS. Kinetics of dissolution of a biocide soda-lime glass powder containing silver nanoparticles. J Nanopart Res. 15, art. no. 1447, 2013.

Chernousova S, Epple M. Silver as antibacterial agent: Ion, nanoparticle, and metal. Angewandte Chemie - Int Ed. 52: 1636-1653, 2013.

Hohnholt MC, Geppert M, Luther EM, Petters C, Bulcke F, Dringen R. Handling of iron oxide and silver nanoparticles by astrocytes. Neurochem Res. 38: 227-239, 2013.

Shao C-Y, Chen S-Z, Su B-H, Tseng YJ, Esposito EX, Hopfinger AJ. Dependence of QSAR models on the selection of trial descriptor sets: A demonstration using nanotoxicity endpoints of decorated nanotubes. J Chem Inform Model. 53: 42-158, 2013.

Berndt S, Wesarg F, Wiegand C, Kralisch D, Muller FA. Antimicrobial porous hybrids consisting of bacterial nanocellulose and silver nanoparticles. Cellulose. 20: 771-783, 2013.

Badwaik VD, Vangala LM, Pender DS, Willis CB, Aguilar ZP, Gonzalez MS, Paripelly R, Dakshinamurthy R. Size-dependent antimicrobial properties of sugarencapsulated gold nanoparticles synthesized by a green method. Nanosc Res Lett. 2012.

Gromadzka-Ostrowska J, Dziendzikowska K, Lankoff A, Dobrzynska M, Instanes C, Brunborg G, Gajowik A, Radzikowska J, Wojewodzka M, Kruszewski M. Silver nanoparticles effects on epididymal sperm in rats. Toxicol Lett. 214: 251-258, 2012.

Applerot G, Lellouche J, Lipovsky A, Nitzan Y, Lubart R, Gedanken A, Banin E. Understanding the antibacterial mechanism of CuO nanoparticles: Revealing the route of induced oxidative stress. Small. 8: 3326-3337, 2012.

Deng Z, Zhu H, Peng B, Chen H, Sun Y, Gang X, Jin P, Wang J. Synthesis of PS/Ag nanocomposite spheres with catalytic and antibacterial activities. ACS Appl Mater Interfaces. 4: 5625-5632, 2012.

He W, Zhou Y-Y, Wamer WG, Boudreau MD, Yin J-J. Mechanisms of the pH dependent generation of hydroxyl radicals and oxygen induced by Ag nanoparticles. Biomat. 33: 7547-7555, 2012.

Levard C, Hotze EM, Lowry GV, Brown GE. Environmental transformations of silver nanoparticles: Impact on stability and toxicity. Environ Sci Technol. 46: 6900-6914, 2012.

Hansen SF, Baun A. When enough is enough. Nature Nanotechnol. 7: 409-411, 2012.

Reijnders L. Human health hazards of persistent inorganic and carbon nanoparticles. J Mater Sci. 47: 5061-5073, 2012.

Franze B, Strenge I, Engelhard C. Single particle inductively coupled plasma mass spectrometry: Evaluation of three different pneumatic and piezo-based sample introduction systems for the characterization of silver nanoparticles. J Anal At Spectrom. 27: 1074-1083, 2012.

Czyz K, Dobrzanski Z, Patkowska-Sokola B, Chojnacka K, Nowakowski P. Physicochemical examinations of nanotechnological preparations [Badania fizykochemiczne preparatow nanotechnologiczno-mineralnych]. Przem Chem. 91: 720-724, 2012.

Alonso A, Munoz-Berbel X, Vigues N, Rodriguez-Rodriguez R, MacAnas J, Mas J, Munoz M, Muraviev DN. Intermatrix synthesis of monometallic and magnetic metal/metal oxide nanoparticles with bactericidal activity on anionic exchange polymers. RSC Advances. 2: 4596-4599, 2012.

Liu Z, Zhang T, Ren G, Yang Z. Nano-Ag inhibiting action potential independent glutamatergic synaptic transmission but increasing excitability in rat CA1 pyramidal neurons. Nanotoxicology. 6: 414-423, 2012.

Krishnaraj C, Jagan EG, Ramachandran R, Abirami SM, Mohan N, Kalaichelvan PT. Effect of biologically synthesized silver nanoparticles on Bacopa monnieri (Linn.) Wettst. plant growth metabolism. Process Biochem. 47: 651-658, 2012.

Lan Z, Yang W-X. Nanoparticles and spermatogenesis: How do nanoparticles affect spermatogenesis and penetrate the blood-testis barrier. Nanomed. 7: 579-596, 2012.

Niles MT, Lubell M. Integrative frontiers in environmental policy theory and research. Policy Stud J. 40(Suppl. 1): 41-64, 2012.

Hagendorfer H, Kaegi R, Parlinska M, Sinnet B, Ludwig C, Ulrich A. Characterization of silver nanoparticle products using asymmetric flow field flow fractionation with a multidetector approach - A comparison to transmission electron microscopy and batch dynamic light scattering. Anal Chem. 84: 2678-2685, 2012.

Zitka O, Ryvolova M, Hubalek J, Eckschlager T, Adam V, Kizek R. From amino acids to proteins as targets for metal-based drugs. Curr Drug Metab. 13: 306-320, 2012.

Hamm SC, Shankaran R, Korampally V, Bok S, Praharaj S, Baker GA, Robertson JD, Lee BD, Sengupta S, Gangopadhyay K, Gangopadhyay S. Sputter-deposition of silver nanoparticles into ionic liquid as a sacrificial reservoir in antimicrobial organosilicate nanocomposite coatings. ACS Appl Mat Interfaces. 4: 178-184, 2012.

Alonso A, Munoz-Berbel X, Vigues N, MacAnas J, Munoz M, Mas J, Muraviev DN. Characterization of fibrous polymer silver/cobalt nanocomposite with enhanced bactericide activity. Langmuir. 28: 783-790, 2012.

Huang Z, Jiang X, Guo D, Gu N. Controllable synthesis and biomedical applications of silver nanomaterials. J Nanosci Nanotechnol. 11: 9395-9408, 2011.

Ganesh Prabu P, Senthamarai Selvi E, Selvisabhanayakam Mathivanan V, Pradhap M, Vivekananthan T. Studies on the comparative feed efficacy of Bombyx mori (L.) (Lepidoptera: Bombycidae) fed with silver nanoparticles (AgNps) and Sirulina treated MR 2 mulberry leaves in relation to growth and development. Int J Pharm Bio Sci. 2: 180-189, 2011.

Tseng K-H, Liao Ch-Y, Tien D-Ch. Control release of bactericidal ion by an electronically driven system. 3rd IEEE International NanoElectronics Conference (INEC)/Symposium on Nanoscience and Nanotechnology in China Location: City Univ Hong Kong. Peoples R China, Jan 03-08, 2010. J Nanosci Nanotechnol. 11: 10750-10754, 2011.

Zhang W, Yao Y, Li K, Huang Y, Chen Y. Influence of dissolved oxygen on aggregation kinetics of citrate-coated silver nanoparticles. Environ Pollut. 159: 3757-3762, 2011.

Galdiero S, Falanga A, Vitiello M, Cantisani M, Marra V, Galdiero M. Silver nanoparticles as potential antiviral agents. Molecules. 16: 8894-8918, 2011.

Luther EM, Koehler Y, Diendorf J, Epple M, Dringen R. Accumulation of silver nanoparticles by cultured primary brain astrocytes. Nanotech. 22: 375101, 2011.

Whiteley CM, Valle MD, Jones KC, Sweetman AJ Challenges in assessing the environmental fate and exposure of nano silver. J Phys: Conference Series 304: 012070, 2011.

Venclikova Z, Benada O, Joska L. Monitoring of selenium in oral cavity argyria - A clinical and microscopic study. Neuroendocrinol Lett. 32: 286-291, 2011.

Cady NC, Behnke JL, Strickland AD. Copper-based nanostructured coatings on natural cellulose: Nanocomposites exhibiting rapid and efficient inhibition of a multi-drug resistant wound pathogen, A. baumannii, and mammalian cell biocompatibility in vitro. Adv Funct Mater. 21: 2506-2514, 2011.

Pradhan A, Seena S, Pascoal C, Cassio F. Can Metal Nanoparticles Be a Threat to Microbial Decomposers of Plant Litter in Streams? Microb Ecol. 62: 58-68, 2011.

Kruszewski M, Brzoska K, Brunborg G, Asare N, Dobrzynska M, Dusinska M, Fjellsbo LM, Georgantzopoulou A, Gromadzka-Ostrowska J, Gutleb AC, Lankoff A, Magdolenova Z, Pran ER, Rinna A, Instanes C, Sandberg JW, Schwarze P, Stepkowski T, Wojewodzka M, Refsnes M. Toxicity of Silver Nanomaterials in Higher Eukaryotes (book). Adv Mol Toxicol. 5: 179-218, 2011.

Gschwind S, Flamigni L, Koch J, Borovinskaya O, Groh S, Niemax K, Gunther D. Capabilities of inductively coupled plasma mass spectrometry for the detection of nanoparticles carried by monodisperse microdroplets. J Anal At Spectrom. 26: 1166-1174, 2011.

Khan SS, Kumar EB, Mukherjee A, Chandrasekaran N. Bacterial tolerance to silver nanoparticles (SNPs): Aeromonas punctata isolated from sewage environment. J Basic Microbiol. 51: 183-190, 2011.

Delay M, Dolt T, Woellhaf A, Sembritzki R, Frimmel FH. Interactions and stability of silver nanoparticles in the aqueous phase: Influence of natural organic matter (NOM) and ionic strength. J Chromatogr A. 1218: 4206-4212, 2011.

Zhang W, Yao Y, Sullivan N, Chen Y. Modeling the primary size effects of citrate-coated silver nanoparticles on their ion release kinetics. Environ Sci Technol. 45: 4422-4428, 2011.

Han ZJ, Levchenko I, Kumar S, Yajadda MMA, Yick S, Seo DH, Martin PJ, Peel S, Kuncic Z, Ostrikov K. Plasma nanofabrication and nanomaterials safety. J Phys D: Appl Phys. 44, art. no. 174019, 2011.

Sudheer Khan S, Bharath Kumar E, Mukherjee A, Chandrasekaran N. Bacterial tolerance to silver nanoparticles (SNPs): Aeromonas punctata isolated from sewage environment. J Basic Microbiol. 51: 183-190, 2011.

Thirumurugan G, Dhanaraju MD. Novel biogenic metal Nanoparticles for pharmaceutical applications. Adv Sci Lett. 4: 339-348, 2011.

Shrivastava S, Singh SK, Mukhopadhyay A, Sinha ASK, Mandal RK, Dash D. Negative regulation of fibrin polymerization and clot formation by nanoparticles of silver. Colloids Surf., B. 82: 241-246, 2011.

Raja ASM, Thilagavathi G, Kannaian T. Synthesis of spray dried polyvinyl pyrrolidone coated silver nanopowder and its application on wool and cotton for microbial resistance. Indian J Fibre Text Res. 35: 59-64, 2010.

Zupanc J, Bas E, Erdogmus D. Analysis of Lipid Vesicle Populations from Microscopy Video Sequences. Conference Information: 33rd Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBC 11), AUG 30-SEP 04, 2011 Boston, MA. Annu Inter Conf IEEE Eng Med Biol Soc (EMBC). Book Series: IEEE Engineering in Medicine and Biology Society Conference Proceedings, pp. 5050-5053, 2010.

Yang Z, Liu ZW, Allaker RP, Reip P, Oxford J, Ahmad Z, Ren G. A review of nanoparticle functionality and toxicity on the central nervous system. J Royal Soc Interface. (Suppl. 4)7: S411-S422, 2010.

Sureshkumar M, Siswanto DY, Lee CK. Magnetic antimicrobial nanocomposite based on bacterial cellulose and silver nanoparticles. J Mater Chem. 20: 6948-6955, 2010.

Lansdown ABG. A pharmacological and toxicological profile of silver as an antimicrobial agent in medical devices. Adv Pharmacol Sci., Art. no. 910686, 2010.

Pohanka M, Vlcek V, Kuca K, Bandouchova H, Pikula J. Pesticide sorption in typical Central European soils evaluated using a photometric microplate assay based on acetylcholinesterase inhibition. J Appl Biomed. 8: 41-46, 2010.

Cheruthazhekatt S, Cernak M, Slavicek P, Havel J. Gas plasmas and plasma modified materials in medicine. J Appl Biomed. 8: 55-66, 2010.

Marambio-Jones C, Hoek EMV. A review of the antibacterial effects of silver nanomaterials and potential implications for human health and the environment. J Nanopart Res. 12: 1531-1551, 2010.

Elzey S, Grassian VH. Agglomeration, isolation and dissolution of commercially manufactured silver nanoparticles in aqueous environments. J Nanopart Res. 12: 1945-1958, 2010.

Wong MS, Sun DS, Chang HH. Bactericidal performance of visible-light responsive titania photocatalyst with silver nanostructures. PLOS ONE 5 Art No: e10394, 2010.

Duran N, Marcato PD, De Conti R, Alves OL, Costa FTM, Brocchi M. Potential use of silver nanoparticles on pathogenic bacteria, their toxicity and possible mechanisms of action. J Brazil Chem Soc. 21: 949-959, 2010.

Khorramizadeh MR, Esmail-Nazari Z, Zarei-Ghaane Z, Shakibaie M, Mollazadeh-Moghaddam K, Iranshahi M, Shahverdi AR. Umbelliprenin-coated Fe3O4 magnetite nanoparticles: Antiproliferation evaluation on human Fibrosarcoma cell line (HT-1080). Mat Sci Eng C. 30: 1038-1042, 2010.

Mortazavi V, Mehdikhani Nahrkhalaji M, Fathi MH, Mousavi SB, Nasr Esfahani B. Antibacterial effects of sol-gel-derived bioactive glass nanoparticle on aerobic bacteria. J Biom Mat Research - A. 94: 160-168, 2010.

Dobrzanski Z, Zygadlik K, Patkowska-Sokola B, Nowakowski P, Janczak M, Sobczak A, Bodkowski R. Efficiency of nanosilver and mineral sorbents in reduction of ammonia emission from animal manure. [Efektywnosc nanosrebra i sorbentow mineralnyeh w redukcji emisji amoniaku z odchodow zwierzcych]. Przemysl Chemiczny. 89: 348-351, 2010.

El-Rafie MH, Mohamed AA, Shaheen ThI, Hebeish A. Antimicrobial effect of silver nanoparticles produced by fungal process on cotton fabrics. Carbohydr Polym. 80: 779-782, 2010.

Liu J, Hurt RH. Ion release kinetics and particle persistence in aqueous nano-silver colloids. Environ Sci Technol. 44: 2169-2175, 2010.

Perry DA, Cordova JS, Smith LG, Son H-J, Schiefer EM, Dervishi E, Watanabe F, Biris AS. Study of adsorption of aminobenzoic acid isomers on silver nanostructures by surface-enhanced infrared spectroscopy. J Phys Chem C. 113: 18304-18311, 2009.

Kilinc E, Lepane V, Viitak A, Gumgum B. Off-line determination of trace silver in water samples and standard reference materials by cloud point extraction-atomic absorption spectrometry. Proc Estonian Academy Sci. 58: 190-196, 2009.

Panyala NR, Pena-Mendez EM, Havel J. Gold and nano-gold in medicine: Overview, toxicology and perspectives. J Appl Biomed. 7: 75-91, 2009.

Liu ZW, Ren GG, Zhang T, Yang Z. Action potential changes associated with the inhibitory effects on voltage-gated sodium current of hippocampal CA1 neurons by silver nanoparticles. Toxicology. 264: 179-184, 2009.

Gardner GE, Jones MG. Bacteria buster: Testing Antibiotic Properties of SWilver Nanoparticles. Amer Biol Teacher. 71: 231-234, 2009.

Shrivastava S, Bera T, Singh SK, Singh G, Ramachandrarao P, Dash D. Characterization of Antiplatelet Properties of Silver Nanopartides. ACS Nano. 3: 1357-1364, 2009.

Tejral G, Panyala NR, Havel J. Carbon nanotubes: toxicological impact on human health and environment. J Appl Biomed. 7: 1-13, 2009.

Tripathy SK. Soft-chemical synthesis and photoluminescence studies of poly-(vinyl) alcohol-stabilized (Ag)(N +/- 10(N=82-3049)) nanoclusters. Colloids Surf A. 331: 202-205, 2008.

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