Journal of APPLIED BIOMEDICINE
ISSN 1214-0287 (on-line)
ISSN 1214-021X (printed)

Volume 7 (2009), No 2, p 93-99




Is a high dose of Huperzine A really suitable for pretreatment against high doses of soman?

Jana Zdarova Karasova, Jiri Bajgar, Ladislav Novotny, Kamil Kuca

Address: Jana Zdarova Karasova, Faculty of Military Health Sciences, Department of Toxicology, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic
karasova@pmfhk.cz

Received 12th February 2009.
Revised 27th March 2009.
Published online 30th April.

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SUMMARY
Huperzine A (Hup A) is a reversible AChE inhibitor that crosses the blood-brain barrier. It is presently approved for, or is in a course of clinical trials for, the treatment of Alzheimer's disease. This compound has also been successfully tested for the pretreatment of organophosphate poisoning. Organophosphate nerve agents are potent irreversible inhibitors of acetylcholinesterase in the central and also in the peripheral compartment. In this study Hup A in a higher dose (500 micro g/kg) was tested as a prophylaxis against a high, mainly centrally acting, nerve agent (soman). According to the results obtained, Hup A in this dosage was not able to protect AChE against soman in both the peripheral and central compartments. The effect of Hup A and soman was found to be additive and all animal subjects died.

KEY WORDS
Huperzine A; soman; brain; nerve agent; acetylcholinesterase; pretreatment


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CITED

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