ISSN 1214-0287 (on-line)
ISSN 1214-021X (printed)

Volume 7 (2009), No 2, p 101-109

Glutathione, glutathione-dependent enzymes and antioxidant status in gastric carcinoma patients

Palanisamy Pasupathi, Ganesan Saravanan, Palanisamy Chinnaswamy, Govindaswamy Bakthavathsalam

Address: Palanisamy Pasupathi, Head-Department of Clinical Biochemistry, Institute of Laboratory Medicine, K. G. Hospital and Post Graduate Medical Institute, Coimbatore-641 018, Tamil Nadu, India

Received 24th September 2008.
Revised 5th January 2009.
Published online 15th March 2009.

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Oxidative stress plays an important role in malignant transformation and is postulated to be associated with increased lipid peroxidation. The aim of this study was to determine the extent of lipid peroxidation with the antioxidant status in patients with gastric cancer. The study population consisted of fifty newly diagnosed gastric cancer patients and an equal number of age- and sex-matched healthy control subjects. Lipid peroxidation as evidenced by thiobarbutric acid reactive substances (TBARS), and also the status of enzymatic (superoxide dismutase - SOD, catalase - CAT, glutathione peroxidase - GPx, glutathione reductase - GR, glutathione S-transferase - GST) and non-enzymatic (reduced glutathione - GSH) antioxidants, were determined. Enhanced lipid peroxidation with concomitant depletion of antioxidants was observed in gastric cancer patients as compared to healthy control subjects. The present study highlights the occurrence of lipid peroxidation and possible breakdown of antioxidant status in patients with gastric carcinoma.

gastric cancer; lipid peroxidation; antioxidants; glutathione; GSH-dependent enzymes

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