Journal of APPLIED BIOMEDICINE
ISSN 1214-0287 (on-line)
ISSN 1214-021X (printed)

Volume 7 (2009), No 3, p 137-142




Effect of desmopressin on hemochromocytometric and clotting parameters in healthy blood donor dogs

Elisabetta Giudice, Claudia Giannetto, Stefania Casella, Giuseppe Arcuri, Giuseppe Piccione

Address: Giuseppe Piccione, Dipartimento di Scienze Sperimentali e Biotecnologie Applicate, Facolta di Medicina Veterinaria, Universita degli Studi di Messina, Polo Universitario dell'Annunziata, 98168, Messina, Italy
giuseppe.piccione@unime.it

Received 2nd July 2009.
Revised 20th July 2009.
Published online 1st September 2009.

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SUMMARY
Six clinically healthy blood donor dogs were used to evaluate the effect of desmopressin (DDAVP) on haemochromocytometric and clotting parameters,. They received subcutaneously a physiological solution (placebo) and DDAVP (1microg/kg) with a two-weeks wash-out period between treatments. Blood samples were collected immediately before the injection, after 30 minutes, then after 1, 2, 3, 4, 5 and 6 hours. Two-way repeated measure analysis of variance (ANOVA) showed no significant effect of DDAVP vs placebo, except for white blood cell (WBC) count, and in particular on neutrophils. In conclusion, DDAVP administration in healthy donor dogs does not induce modification in blood cell count and clotting parameters, except of WBC.

KEY WORDS
desmopressin; clotting time parameters; hemochromocytometric parameters; dog; blood donor


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CITED

Giudice E, Giannetto C, Gianesella M. Effect of desmopressin on immune-mediated haemorrhagic disorders due to canine monocytic ehrlichiosis: a preliminary study. J Vet Pharmacol Therap. 33: 610-614, 2010.

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