Journal of APPLIED BIOMEDICINE
ISSN 1214-0287 (on-line)
ISSN 1214-021X (printed)

Volume 7 (2009), No 4, p 163-173




Nitric oxide, health and disease

Carlos Kusano Bucalen Ferrari, Eduardo Luzia Franca, Adenilda Cristina Honorio-Franca

Address: Carlos K. B. Ferrari, Biomedical Research Group, "Campus Universitario do Araguaia", Federal University of Mato Grosso (UFMT). Rodovia MT100, Km 3,5, 78698-000, Pontal do Araguaia, Brazil
drcarlosferrari@hotmail.com

Received 4th June 2009.
Revised 5th August 2009.
Published online 25th September 2009.

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SUMMARY
Nitric oxide is a gaseous substance which possesses many important physiological characteristics ranging from its action as a natural immune mechanism to endothelial control of blood pressure. However, it can also generate nitrogen reactive species (peroxynitrite and others), which are involved as a cause of or a consequence of many diseases. This article updates and summarizes the physiological and pathophysiological roles of nitric oxide.

KEY WORDS
peroxynitrite; cancer; cardiovascular diseases; phagocytosis; diabetes mellitus; infection


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