ISSN 1214-0287 (on-line), ISSN 1214-021X (printed)
J Appl Biomed
Volume 8 (2010), No 1, p 19-22
DOI 10.2478/v10136-009-0003-y

Alternative haematotoxicological testing

Josef Berger

Address: Josef Berger, Faculty of Health and Social Studies, University of South Bohemia, Emy Destinove, 370 05 Ceske Budejovice, Czech Republic
berger@jcu.cz

Received 16th October 2009.
Revised 22nd November 2009.
Published online 5th January 2010.

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SUMMARY
Standard haematological procedures in preclinical subchronic and chronic toxicity studies are carried out on dogs, rats and other mammals. In vitro clonic assays CFU-GM, BFU-E, CFU-E, CFU-Mgkr and pluripotent stem cells are used in screening candidate compounds to predict acute cytopenias, but they are not able to reveal the risk of suppression which can develop after repeated administration. No in silico studies have yet been published in haematotoxicology. More recent haematotoxicological in vivo models represent invertebrates: they can be used in both ecotoxicology and in the screening of myelotoxicity.

KEY WORDS
myelotoxicity; alternative testing; in vitro; in silico; invetebrate


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