ISSN 1214-0287 (on-line), ISSN 1214-021X (printed)
J Appl Biomed
Volume 8 (2010), No 2, p 93-109
DOI 10.2478/v10136-009-0014-8

Circadian time structure of fatty acids and vascular monitoring

Germaine Cornelissen, Claudio Galli, Franz Halberg, Fabien De Meester, Patrizia Rise, Agnieszka Wilczynska-Kwiatek, Ram B Singh, Francis Guillaume

Address: Germaine Cornelissen, Halberg Chronobiology Center, University of Minnesota - MMC 8609, 420 Delaware Street SE, Minneapolis, MN 5545, USA
corne001@umn.edu

Received 19th March 2010.
Revised 26th April 2010.
Published online 27th April 2010.

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SUMMARY
The circadian variation of 40 circulating fatty acids related variables was assessed from one man (F) and one woman (G). Each provided blood samples by finger pricking at about 4-hour intervals for 24 hours. A statistically significant rhythm was found in 65% of the variables after data expressed as a percentage of their 24-hour mean values were pooled. In particular, a putative circadian rhythm for n-3 and n-6 fatty acids deserves exploration. The predominant 12-hour component found to characterize the n-3 status of G may stem from the odd schedule she followed on the day of study, as attested by alterations in the time structure of her blood pressure on the day of study, as compared to similarly collected data on 33 other Sundays in 2009 available as control information. Circadian vascular characteristics are sensitive markers of loads, including the rest-activity schedule.

KEY WORDS
blood pressure; cholesterol; circadian; highly unsaturated fatty acids (HUFA); omega-3 (n-3) and omega-6 (n-6) fatty acids

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