ISSN 1214-0287 (on-line), ISSN 1214-021X (printed)|
J Appl Biomed
Volume 8 (2010), No 2, p 55-66
The applications of gas plasma and plasma modified materials in the emerging fields of medicine such as dentistry, drug delivery, and tissue engineering. Plasma sterilization of both living and non-living objects is safe, fast and efficient; for example plasma sterilization of medical equipment quickly removes microorganisms with no damage to the tiny delicate parts of the equipment and in dentistry it offers a non-toxic, painless bacterial inactivation of tissues from a dental cavity. Devices that generate plasma inside the root canal of a tooth give better killing efficiency against bacteria without causing any harm to the surrounding tissues. Plasma modified materials fulfill the requirements for bioactivity in medicine; for example, the inclusion of antimicrobial agents (metal nano particles, antimicrobial peptides, enzymes, etc.) in plasma modified materials (polymeric, metallic, etc) alters them to produce superior antibacterial biomedical devices with a longer active life. Thin polymer films or coating on surfaces with different plasma processes improves the adherence, controlled loading and release of drug molecules. Surface functionalization by plasma treatment stimulates cell adhesion, cell growth and the spread of tissue development. Plasma applications are already contributing significantly to the changing face of medicine and future trends are discussed in this paper.
plasma; sterilization; dentistry; surface functionalization; drug delivery; tissue engineering
Aumsuwan N, McConnell MS, Urban MW: Tunable antimicrobial polypropylene surfaces: Simultaneous attachment of penicillin (Gram +) and gentamicin (Gram -). Biomacromolecules 10:623-629, 2009.
Bacakova L, Filova E, Rypacek F, Svorcik V, Stary V: Cell adhesion on artificial materials for tissue engineering. Physiol Res 53(Suppl. 1):S35-S45, 2004.
Bogaerts A, Neyts E, Gijbels R, Mullen J: Gas discharge plasmas and their applications: Review. Spectrochim Acta Part B 57:609-658, 2002.
Braithwaite NSJ: Introduction to gas discharges. Plasma Sources Sci Technol 9:517-527, 2000.
Canal C, Gaboriau F, Vilchez A, Erra P, Celma MG, Esquena J: Topographical and wettability effects of post-discharge plasma treatments on macroporous polystyrene-divinylbenzene solid foams. Plasma Process Polym 6:686-692, 2009.
Chen G, Zhou M, Chen S, Guohua L, Yao J: Nanolayer biofilm coated on magnetic nanoparticles by using a dielectric barrier discharge glow plasma fluidized bed for immobilizing an antimicrobial peptide. Nanotechnology 20:465706, 2009.
Chen Y, Zheng X, Xie Y, Ji H, Chuanxian D: Antibacterial properties of vacuum plasma sprayed titanium coatings after chemical treatment. Surf Coat Technol 204:685-690, 2009.
Chu PK, Chena JY, Wanga LP, Huang N: Plasma-surface modification of biomaterials. Mater Sci Eng R Rep 36:143-206, 2002.
Conrads H, Schmidt M: Plasma generation and plasma sources. Plasma Sources Sci Technol 9:441-454, 2000.
Conte A, Buonocore GG, Sinigaglia M, Lopez LC, Favia P, Agostino R, Del Nobile MA: Antimicrobial activity of immobilized lysozyme on plasma-treated polyethylene films. J Food Prot 71:119-125, 2008.
Crow S, Smith JH: Gas plasma sterilization: Application of space-age technology. Infect Control Hosp Epidemiol 16:483-487, 1995.
Daniel A, Pen LC, Archambeau C, Reniers F: Use of a PECVD-PVD process for the deposition of copper containing organosilicon thin films on steel. Appl Surf Sci 256:82-85, 2009.
Denes FS, Manolache S: Macromolecular plasma-chemistry: An emerging field of polymer science. Prog Polym Sci 29:815-885, 2004.
Desmet T, Morent R, Geyter N, Leys C, Schacht E, Dubruel P: Nonthermal plasma technology as a versatile strategy for polymeric biomaterials surface modification: A Review. Biomacromolecules 10:2351-2378, 2009.
Eisenbrey JR, Hsu J, Wheatley MA: Plasma sterilization of poly lactic acid ultrasound contrast agents: surface modification and implications for drug delivery. Ultrasound Med Biol 35:1854-1862, 2009.
Favia P, Sardella E, Lopez L, Laera S, Milella A, Pistillo B, Intranuovo F, Nardulli M, Gristina R, D'Agostino R: Plasma assisted surface modification processes for biomedical materials and devices. NATO ASI Ser A 10:203-225, 2008.
Fridman G, Peddinghaus M, Ayan H, Fridman A, Balasubramanian M, Gutsol A, Brooks A, Friedman G: Blood coagulation and living tissue sterilization by floating-electrode dielectric barrier discharge in air. Plasma Chem Plasma Process 26:425-442, 2006.
Fridman G, Brooks AD, Balasubramanian M, Fridman A, Gutsol A, Vasilets VN, Ayan H, Friedman G: Comparison of direct and indirect effects of non-thermal atmospheric-pressure plasma on bacteria. Plasma Process Polym 4:370-375, 2007.
Fridman G, Friedman G, Gutsol A, Shekhter AB, Vasilets VN, Fridman A: Applied plasma medicine. Plasma Process Polym 5:503-533, 2008.
Gaunt LF, Beggs CB, Georghiou GE: Bactericidal action of the reactive species produced by gas-discharge nonthermal plasma at atmospheric pressure: A review. IEEE Trans Plasma Sci 34:1257-1269, 2006.
Gomathi N, Sureshkumar A, Neogi S: RF plasma-treated polymers for biomedical applications. Curr Sci 94:1478-1486, 2008.
Goree J, Liu B, Drake D, Stoffels E: Killing of S. mutans bacteria using a plasma needle at atmospheric pressure. IEEE Trans Plasma Sci 34:1317-1324, 2006.
Griffiths N: Low-temperature sterilization using gas plasmas. Med Device Technol 4:37-40, 1993.
Gupta G, Anjum N: Plasma and radiation-induced graft modification of polymers for biomedical applications. Adv Polym Sci 162:35-61, 2003.
Gweon B, Kim DB, Moon SY, Choe W: Escherichia coli deactivation study controlling the atmospheric pressure plasma discharge conditions. Curr Appl Phys 9:625-628, 2009.
Halfmann H, Bibinov N, Wunderlich J, Awakowicz P: A double inductively coupled plasma for sterilization of medical devices. J Phys D Appl Phys 40:4145-4154, 2007.
Hayashi N, Guan W, Tsutsui S, Tomari T, Hanada Y: Sterilization of medical equipment using radicals produced by oxygen/water vapor RF plasma. Jpn J Appl Phys 10B 45:8358-8363, 2006.
Herrmann HW, Henins I, Park J, Selwyn GS: Decontamination of chemical and biological warfare agents using an atmospheric pressure plasma jet. Phys Plasmas 6:2284-2289, 1999.
Ji J, Zhang W: Bacterial behaviors on polymer surfaces with organic and inorganic antimicrobial compounds. J Biomed Mater Res Part A 10:448-453, 2007.
Jiang C, Chen MT, Gorur A, Schaudinn C, Jaramillo DE, Costerton JW, Sedghizadeh PP, Vernier PT, Gundersen MA: Nanosecond pulsed plasma dental probe. Plasma Process Polym 6:479-483, 2009.
Kim JS, Kuk E, Yu KN, Kim JH, Park SJ, Lee HJ, Kim SH, Park YK, Park YH, Hwang CY, Kim YK, Lee YS, Jeong DH, Cho MH: Antimicrobial effects of silver nanoparticles. Nanomed Nanotechnol Biol Med 3:95-101, 2007.
Klima M, Janca J, Kapicka V, Slavicek P, Saul P: Zpusob vytvareni fyzikalne a chemicky aktivniho prostredi plazmovou tryskou a plazmová tryska. Patent CZ 147698, 12. 5. 1998.
Klima M, Janca J, Kapicka V, Slavicek P, Saul P: The method of making a physically and chemically active environment by means of a plasma jet and the related plasma jet. Patent US 6, 525, 481, 2003; Patent EP 1077021, 2005. Prior 12. 5. 1998.
Kylian O, Rauscher H, Gilliland D, Bretagnol F, Rossi F: Removal of model proteins by means of low-pressure inductively coupled plasma discharge. J Phys D Appl Phys 41:095201, 2008.
Laroussi M: Low lemperature plasma-based sterilization: Overview and state-of-the-art. Plasma Process Polym 2:391-400, 2005.
Laroussi M: The biomedical application of plasma: A brief history of the development of a new field of research. IEEE Trans Plasma Sci 36:1612-1614, 2008.
Laroussi M, Tendero C, Lu X, Alla S, Hynes WL: Inactivation of bacteria by the plasma pencil. Plasma Process Polym 3:470-473, 2006.
Laroussi M, Hynes W, Akan T, Lu X, Tendero C: The plasma pencil: A Source of hypersonic cold plasma bullets for biomedical applications. IEEE Trans Plasma Sci 36:1298-1299, 2008.
Lee HW, Kim GJ, Kim JM, Park JK, Lee JK, Kim GC: Tooth bleaching with nonthermal atmospheric pressure plasma. J Endod 35:587-591, 2009.
Lerouge S, Wertheimer MR, Yahia LH: Plasma sterilization: A review of parameters, mechanisms, and limitations. Plasmas Polym 6:175-188, 2001.
Li B, Liua X, Menga F, Chang J, Dinga C: Preparation and antibacterial properties of plasma sprayed nano-titania/silver coatings. Mater Chem Phys 118:99-104, 2009.
Lin SM, Swanzy, Jacobs PT: Method of hydrogen peroxide plasma sterilization. U S patent 5 876 666, 1999.
Losic D, Cole MA, Dollmann B, Vasilev K, Griesser HJ: Surface modification of nanoporous alumina membranes by plasma polymerization. Nanotechnology 19:245704, 2008.
Lu X, Cao Y, Yang P, Xiong Q, Xiong Z, Xian Y, Pan Y: An RC plasma device for sterilization of root canal of teeth. IEEE Trans Plasma Sci 37:668-673 2009.
Lucchesi C, Ferreira BMP, Duek EAR, Santos AR. Jr, Joazeiro PP: Increased response of vero cells to PHBV matrices treated by plasma. J Mater Sci Mater Med 19:635-643, 2008.
Martines E, Zuin M, Cavazzana R, Gazza E, Serianni G, Spagnolo S, Spolaore M, Leonardi A, Deligianni V, Brun P, Aragona M, Castagliuolo I, Brun P: A novel plasma source for sterilization of living tissues. New J Phys 11:115014, 2009.
Miao H, Jierong C: Inactivation of Escherichia coli and properties of medical poly(vinyl chloride) in remote-oxygen plasma. Appl Surf Sci 255:5690-5697, 2009.
Miola M, Ferraris S, Nunzio SD, Robotti PF, Bianchi G, Fucale G, Maina G, Cannas M, Gatti S, Masse A, Brovarone CV, Verne E: Surface silver-doping of biocompatible glasses to induce antibacterial properties. Part II: Plasma sprayed glass-coatings. J Mater Sci Mater Med 20:741-749, 2009.
Montie C, Kelly WK, Roth R: Overview of research using the one-atmosphere uniform glow discharge plasma for sterilization of surfaces and materials. IEEE Trans Plasma Sci 28:41-50, 2000.
Moon Y, Kim DB, Gweon B, Choe W, Song HP, Jo C: Feasibility study of the sterilization of pork and human skin surfaces by atmospheric pressure plasmas. Thin Solid Films 517:4272-4275, 2009.
Moreau M, Orange N, Feuilloley MGJ: Non-thermal plasma technologies: New tools for bio-decontamination. Biotechnol Adv 26:610-617, 2008.
Nie QY, Cao, Ren CS, Wang DZ, Kong MG: A two-dimensional cold atmospheric plasma jet array for uniform treatment of large-area surfaces for plasma medicine. New J Phys 11:115015, 2009.
Noyce JO, Michels H, Keevil CW: Potential use of copper surfaces to reduce survival of epidemic methicillin-resistant Staphylococcus aureus in the healthcare environment. J Hosp Infect 63:289-297, 2006.
Oehr C: Plasma surface modification of polymers for biomedical use. Nucl Instrum Methods Phys Res B 208:40-47, 2003.
Ozcan C, Zorlutuna P, Hasirci V, Hasirci N: Influence of oxygen plasma modification on surface free energy of PMMA films and cell attachment. Macromol Symp 269:128-137, 2008.
Panyala NR, Pena-Mendez EM, Havel J: Silver or silver nanoparticles: A hazardous threat to the environment and human health? J Appl Biomed 6:117-129, 2008.
Rai M, Yadav A, Gade A: Silver nanoparticles as a new generation of antimicrobials. Biotechnol Adv 27:76-83, 2009.
Ruparelia JP, Chatterjee AK, Duttagupta SP, Mukherji S: Strain specificity in antimicrobial activity of silver and copper nanoparticles. Acta Biomaterialia 4:707-716, 2008.
Santos MI, Pashkuleva I, Alves CM, Gomes ME, Fuchs S, Unger RE, Reisab RL, Kirkpatrick CJ: Surface-modified 3D starch-based scaffold for improved endothelialization for bone tissue engineering. Mater Chem 19:4091-4101, 2009.
Sartori S, Rechichi A, Vozzi G, D'Acunto M, Heine E, Giusti P, Ciardelli G: Surface modification of a synthetic polyurethane by plasma glow discharge: Preparation and characterization of bioactive monolayers. React Funct Polym 68:809-821, 2008.
Sharma VK, Yngard RA, Lin Y: Silver nanoparticles: Green synthesis and their antimicrobial activities. Adv Colloid Interface Sci 145:83-96, 2009.
Shenton MJ, Stevens GC: Surface modification of polymer surfaces: Atmospheric plasma versus vacuum plasma treatments. J Phys D Appl Phys 34:2761-2768, 2001.
Shinonaga Y, Arita K: Surface modification of stainless steel by plasma-based fluorine and silver dual ion implantation and deposition. Dent Mater 28:735-742, 2009.
Silver S, Phung LT: Bacterial heavy metal resistance: New surprises. Annu Rev Microbiol 89:753-789, 1996.
Sladek REJ, Stoffels E, Walraven R, Tielbeek PJA, Koolhoven RA: Plasma treatment of dental cavities: A feasibility study. IEEE Trans Plasma Sci 32:1540-1543, 2004.
Sodhi RNS, Sahi VP, Mittelman MW: Application of electron spectroscopy and surface modification techniques in the development of anti-microbial coatings for medical devices. J Electron Spectros Relat Phenomena 121:249-264, 2001.
Sohbatzadeh F, Colagar AH, Mirzanejhad S, Mahmodi S: E. coli, P. aeruginosa, and B. cereus bacteria sterilization using afterglow of non-thermal plasma at atmospheric pressure. Appl Biochem Biotechnol 160:1978-1984, 2009.
Tendero C, Tixier C, Tristant P, Desmaison J, Leprince P: Atmospheric pressure plasmas: A review. Spectrochim Acta Part B 61:2-30, 2006.
Trompeter FJ, Neff WJ, Franken O, Heise M, Neiger M, Shuhai L: Reduction of Bacillus subtilis and Aspergillus niger spores using nonthermal atmospheric gas discharges. IEEE Trans Plasma Sci 30:1416-1423, 2002.
Vasilev K, Poh Z, Kant K, Chan J, Michelmore A, Losic D: Tailoring the surface functionalities of titania nanotube arrays. Biomaterials 31:532-540, 2010.
Weir E, Lawlor A, Whelan A, Regan F: The use of nanoparticles in anti-microbial materials and their characterization. Analyst 133:835-845, 2008.
Xingmin S, Yukang Y, Yanzhou S, Wang Y, Fengling P, Yuchang Q: Experimental research of inactivation effect of low-temperature plasma on bacteria. Plasma Sci Technol 8:569-572, 2006.
Yool HS, Kim TG, Park TG: Surface-functionalized electrospun nanofibers for tissue engineering and drug delivery. Adv Drug Delivery Rev 61:1033-1042, 2009.
Zhang W, Zhang Y, Ji J, Yan Q, Huang A, Chu PK: Antimicrobial polyethylene with controlled copper release. J Biomed Mater Res Part A 83:838-844, 2007.
Zhang X, Huang J, Liu X, Peng L, Guo L, Lv G, Chen W, Feng K, Yang S: Treatment of Streptococcus mutans bacteria by a plasma needle. J Appl Phys 105:1063, 2009.
Chiper A, Borcia G. Argon Versus Helium Dielectric Barrier Discharge for Surface Modification of Polypropylene and Poly(methyl methacrylate) Films. Plasma Chem Plasma Process. 33: 553-568, 2013.
Thiyagarajan M. A Portable atmospheric air plasma device for biomedical treatment applications. J Med Devices. Transactions of the ASME 77, art. no. 011007, 2013.
Wise SG, Waterhouse A, Kondyurin A, Bilek MM, Weiss AS. Plasma-based biofunctionalization of vascular implants. Nanomed. 7: 1907-1916, 2012.
Thiyagarajan M, Sarani A, Gonzales X. Characterization of Portable Resistive Barrier Plasma Jet and Its Direct and Indirect Treatment for Antibiotic Resistant Bacteria and THP-1 Leukemia Cancer Cells. IEEE Trans Plasma Sci. 40: 3533-3545, 2012.
Mariotti D, Patel J, Svrcek V, Maguire P. Plasma-Liquid Interactions at Atmospheric Pressure for Nanomaterials Synthesis and Surface Engineering. Plasma Processes Polym. 9: 1074-1085, 2012.
Waterhouse A, Wise SG, Yin Y, Wu BC, James B, Zreiqat H, McKenzie DR, Bao SS, Weiss AS, Ng MKC, Bilek MMM. In vivo biocompatibility of a plasma-activated, coronary stent coating. Biomater. 33: 7984-7992, 2012.
Radic N, Obradovic BM, Kostic M, Dojcinovic B, Kuraica MM, Cernak M. Deposition of silver ions onto DBD and DCSBD plasma treated nonwoven polypropylene. Surf Coat Technol. 206: 5006-5011, 2012.
Chen R, Bayon Y, Hunt JA. Preliminary study on the effects of ageing cold oxygen plasma treated PET/PP with respect to protein adsorption. Colloids Surf B. 96: 62-68, 2012.
Walsh JL, Olszewski P, Bradley JW. The manipulation of atmospheric pressure dielectric barrier plasma jets. Plasma Sources Sci Technol. 21: 034007, 2012.
De Cooman Hh Desmet T, Callens F, Dubruel P. Role of radicals in UV-initiated postplasma grafting of poly-epsilon-caprolactone: An electron paramagnetic resonance study. J Polym Sci, Part A: Polym Chem. 50: 2142-2149, 2012.
Borcia G, Cazan R, Borcia C. DBD surface modification of polymers in relation to the spatial distribution of reactive oxygen species. Plasma Chem Plasma Process. 31: 729-740, 2011.
Berger J. The age of biomedicine: current trends in traditional subjects. J Appl Biomed. 9: 57-61, 2011.
Dobrynin D, Wu A, Kalghatgi S, Park S, Shainsky N, Wasko K, Dumani E, Ownbey R, Joshi S, Sensenig R, Brooks A. Live pig skin tissue and wound toxicity of cold plasma treatment. Plasma Med. 1: 93-108, 2011.