ISSN 1214-0287 (on-line), ISSN 1214-021X (printed)
J Appl Biomed
Volume 8 (2010), No 4, p 209-211
DOI 10.2478/v10136-009-0029-1

Assessing variability in neonatal blood pressure, notably in hypotension

Germaine Cornelissen, Franz Halberg, Elena Vasilievna Syutkina, Galina Victorovna Yatsyk, Anatoly Victorovich Masalov, Othild Schwartzkopff, Dana Johnson

Address: Germaine Cornelissen, Halberg Chronobiology Center, University of Minnesota - MMC 8609, 420 Delaware Street SE, Minneapolis, MN 5545, USA

Received 10th March 2010.
Revised 14th June 2010.
Published online 2nd July 2010.

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New reports corroborate our prior finding that hypotension in infancy is associated with impaired neurodevelopment later in childhood. We had also found that neurological deficit is further associated with a more pronounced circadian variation in transcutaneous pO2 (tcpO2). New evidence in adulthood prompts the recommendation to automatically monitor vital signs for continued surveillance, relying on the methods of chronobiology for data analysis as-one-goes. This applies notably early in extra-uterine life when infants may be particularly sensitive to ischemic cerebral injury secondary to systemic hypotension. Monitoring at this sensitive lifetime stage has also provided a glimpse of unseen effects of the cosmos on the patterns of blood pressure variability, detected by chronomics.

blood pressure; chronomics; circadian; ischemic cerebral injury; hypotension; neurological development

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