ISSN 1214-0287 (on-line), ISSN 1214-021X (printed)|
J Appl Biomed
Volume 8 (2010), No 4, p 209-211
New reports corroborate our prior finding that hypotension in infancy is associated with impaired neurodevelopment later in childhood. We had also found that neurological deficit is further associated with a more pronounced circadian variation in transcutaneous pO2 (tcpO2). New evidence in adulthood prompts the recommendation to automatically monitor vital signs for continued surveillance, relying on the methods of chronobiology for data analysis as-one-goes. This applies notably early in extra-uterine life when infants may be particularly sensitive to ischemic cerebral injury secondary to systemic hypotension. Monitoring at this sensitive lifetime stage has also provided a glimpse of unseen effects of the cosmos on the patterns of blood pressure variability, detected by chronomics.
blood pressure; chronomics; circadian; ischemic cerebral injury; hypotension; neurological development
Augustine EM, Spielman DM, Barnes PD, Sutcliffe TL, Dermon JD, Mirmiran M, Clayton DB, Ariagno RL: Can magnetic resonance spectroscopy predict neurodevelopmental outcome in very low birth weight preterm infants? J Perinatol 28:611-618, 2008.
Batton B, Zhu X, Fanaroff J, Kirchner L, Berlin S, Wilson-Costello D, Walsh M: Blood pressure, anti-hypotensive therapy, and neurodevelopment in extremely preterm infants. J Pediatr 154:351-357, 2009.
Cornelissen G, Halberg F: Chronomedicine. In Armitage P, Colton T (eds.): Encyclopedia of Biostatistics, 2nd ed. John Wiley & Sons Ltd; Chichester 2005, p. 796-812.
Cornelissen G, Halberg F, Tarquini B, Mainardi G, Panero C, Cariddi A, Sorice V, Cagnoni M: Blood pressure rhythmometry during the first week of human life. In Tarquini B (ed.): Social Diseases and Chronobiology: Proc. III Int. Symp. Social Diseases and Chronobiology, Florence, Nov. 29, 1986. Bologna: Societa Editrice Esculapio; 1987, p. 113-122.
Cornelissen G, Halberg F, Otsuka K, Singh RB, Chen CH: Chronobiology predicts actual and proxy outcomes when dipping fails. Hypertension 49:237-239, 2007.
Halberg F: Chronobiology: methodological problems. Acta Med Rom 18:399-440, 1980.
Halberg F, Cornelissen G, Bingham C, Tarquini B, Mainardi G, Cagnoni M, Panero C, Scarpelli P, Romano S, Marz W, Hellbrugge T, Shinoda M, Kawabata Y: Neonatal monitoring to assess risk for hypertension. Postgrad Med 79:44-46, 1986.
Halberg F, Cornelissen G, Bakken E: Caregiving merged with chronobiologic outcome assessment, research and education in health maintenance organizations (HMOs). Prog Clin Biol Res 341B:491-549, 1990.
Halberg F, Cornelissen G, Otsuka K, Syutkina EV, Masalov A, Breus T, Viduetsky A, Grafe A, Schwartzkopff O: Chronoastrobiology: neonatal numerical counterparts to Schwabe's 10.5 and Hale's 21-year sunspot cycles. In memoriam Boris A. Nikityuk. Int J Prenat Perinat Psychol Med 13:257-280, 2001.
Halberg F, Cornelissen G, Halberg J, Schwartzkopff O: Pre-hypertensive and other variabilities also await treatment. Am J Med 120:e19-e20, 2007, doi:10.1016/j.amjmed.2006.02.045.
Halberg F, Cornelissen G, Otsuka K, Siegelova J, Fiser B, Dusek J, Homolka P, Sanchez de la Pena S, Singh RB: BIOCOS project. Extended consensus on need and means to detect vascular variability disorders (VVDs) and vascular variability syndromes (VVSs). Geronto-Geriatrics: Int J Gerontology-ChronomeGeriatrics 11:119-146, 2008a.
Halberg F, Cornelissen G, Sothern RB, Katinas GS, Schwartzkopff O, Otsuka K: Cycles tipping the scale between death and survival (= "life"). Prog Theor Phys 173 (Suppl.):153-181, 2008b.
Halberg F, Cornelissen G, Wilson D, Singh RB, De Meester F, Watanabe Y, Otsuka K, Khalilov E: Chronobiology and chronomics: detecting and applying the cycles of nature. Biologist 56:209-214, 2009.
Lou HC, Lassen NA, Friis-Hansen B: Impaired autoregulation of cerebral blood flow in the distressed newborn infant. J Pediatr 94:118-121, 1979.
Syutkina EV, Kirdyashkina MA, Cornelissen G, Abramian AS, Grigoriev AE, Yatsyk GV, Golovkina ID, Maslova OI, Halberg F: Near-infrared spectrophotometry (NIRS)-monitored circadian variation of preterm infants' cerebral blood volume and neurological outcome. Int J Prenat Perinat Psychol Med 11:311-328, 1999.
Syutkina EV, Cornelissen G, Yatsyk G, Studenikin M, Baranov A, Halberg F: Over a decade of clinical chrononeonatology and chronopediatrics in Moscow. Neuro Endocrinol Lett 24 (Suppl. 1):132-138, 2003.
Berger J. The age of biomedicine: current trends in traditional subjects. J Appl Biomed. 9: 57-61, 2011.