ISSN 1214-0287 (on-line), ISSN 1214-021X (printed)
J Appl Biomed
Volume 9 (2011) No 3, p 143-149
DOI 10.2478/v10136-009-0033-5

Gentamicin bound to the nanofibre microdispersed oxidized cellulose in the treatment of deep surgical site infections

Petr Lochman, Jiri Paral, Jaromir Koci

Address: Petr Lochman, Department of Field Surgery, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic
lochmpet@seznam.cz; lochmpet@yahoo.com

Received 7th June 2010.
Revised 17th September 2010.
Published online 12th November 2010.

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SUMMARY
The aim of this experimental in vivo study was to examine the effect of topically-used gentamicin bound to microdispersed oxidized cellulose (MDOC) in nanofibre form in the treatment of deep surgical site infections and to compare it with Garamycin Schwamm®. Twelve domestic swine were used in a model of a full-thickness infected dermal wound. The effectiveness of both forms of gentamicin were tested in wound infections caused by Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli. The effectiveness of gentamicin-MDOC and Garamycin Schwamm® were comparable according to microbiological culture findings, with no statistically significant differences. When macroscopically assessed, 100% of the infected wounds treated by gentamicin-MDOC were without signs of infection, compared with only 16.7% when Garamycin Schwamm® was used and this was of statistical significance. Therefore when combined with a nanofibre MDOC carrier, topically-used gentamicin is rendered more effective for the treatment of full-thickness skin infections.

KEY WORDS
gentamicin; microdispersed oxidized cellulose; surgical site infections; Garamycin Schwamm

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CITED

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