Journal of Applied Biomedicine - Ahead of Print
Applying the technology ORBEYETM exoscope in transoral exoscopic laryngeal surgery: single centre prospective study
Richard Holý, *, Tomáš Filipovský, Eva Lukavcová, David Kalfeřt, Pavol Praženica, Petra Dytrych, Jiří Hložek, Jan Rotnágl, Daniel Kovář, Jaromír Astl
J Appl Biomed X:X | DOI: 10.32725/jab.2025.010 
Introduction: ORBEYETM exoscope offers superior visualization with clearer imaging compared to standard methods and supports narrow band imaging (NBI). ORBEYETM provides better visualization of tissue structures, thus increasing the accuracy of the surgical procedure. The systematic use of ORBEYETM in transoral exoscopic laryngeal surgery (TOLES) is rarely documented. This study evaluates the sensitivity and specificity of TOLES using ORBEYETM with white light and NBI modalities. Methods: Between 8/2021 and 8/2024, 84 patients underwent TOLES using ORBEYETM with white light and NBI modes. All surgeries...
Influence of the antidiabetic drug metformin on the aquatic crustacean Daphnia magna
Martina Poncarová, Šárka Klementová, Michal Šorf
J Appl Biomed X:X | DOI: 10.32725/jab.2025.011
Background: The antidiabetic drug metformin has been repeatedly detected in surface waters worldwide. This study investigates the effects of the environmentally relevant concentration of metformin on a non-target aquatic organism - a freshwater crustacean, Daphnia magna, with an emphasis on the stress response of daphnids and the long-term effects on their consecutive generations. Methods: The chronic toxicity test and the consecutive generations test were inspired by the OECD method. The total antioxidant capacity (Trolox equivalent - TEAC), superoxide dismutase (SOD) activity, and catalase (CAT) activity were related to the protein content...