J Appl Biomed 1:169-173, 2003 | DOI: 10.32725/jab.2003.031

Biological activity of binary mixtures of 2,4-D with some aminophosphonates

Janusz Sarapuk^*, Dorota Bonarska, Halina Kleszczyńska

Department of Physics and Biophysics, Agricultural University, Wrocław, Poland

A series of cyclic and acyclic aminophosphonates was synthesized for agrochemical application. The compounds differed in the substituents at the carbon, nitrogen and phosphorus atoms. Their potential biological activity was checked by studying their hemolytic potency, since hemolysis of erythrocytes by various compounds was found earlier to be a good indicator of their pesticidal efficiency. A series of hemolytic experiments permitted us to check the pesticidal efficiency of aminophosphonates and to determine what structural features of aminophosphonates are responsible for it.
Parallelly, we studied the hemolytic efficiency of binary mixtures of the aminophosphonates with the well-known herbicide 2,4-dichlorophenoxyacetic acid (2,4-D...) The aim was to check if potential biological efficiencies could be enhanced in comparison with those found for individual components due to interactions between aminophosphonates and 2,4-D. An analysis of the effects binary mixtures was carried out by constructing graphs for both components of binary mixtures that give the same hemolysis (the isobole method).

Keywords: aminophosphonates; biological activity; erythrocytes; binary mixtures

Received: May 30, 2003; Published: July 31, 2003  Show citation