J Appl Biomed 1:207-211, 2003 | DOI: 10.32725/jab.2003.037

Reactivation of organophosphate inhibited acetylcholinesterase activity by α,ω-bis-(4-hydroxyiminomethylpyridinium)alkanes in vitro

Kamil Kuča^a,*, Jiří Patočka^a,b, Jiří Cabal^a

^a Department of Toxicology, Military Medical Academy, Hradec Králové, Czech Republic

^b Department of Radiology and Toxicology, Faculty of Health and Social Studies, South Bohemia University, České Budějovice, Czech Republic

In this article, we have followed up the relationship between the ability to reactivate acetylcholinesterase inhibited by organophosphorus compounds and the length of linking chain between two 4-hydroxyiminomethylpyridinium rings of acetylcholinesterase reactivators. α,ω-bis(4-hydroxyiminomethylpyridinium) alkanes have been used as the tested acetylcholinesterase reactivators. These oximes differ in the number of methylene groups on the connecting chain. A three or four membered linking chain seems to be the ideal length for the satisfactory reactivation potency with the exception of reactivators of cyclosarin-inhibited acetylcholinesterase. In this case, the most efficacious acetylcholinesterase reactivator has one methylene group on the connecting chain.

Keywords: acetylcholinesterase; organophosporus compounds; tabun; sarin; cyclosarin; VX

Received: May 24, 2003; Revised: September 2, 2003; Published: July 31, 2003  Show citation