J Appl Biomed 3:37-46, 2005 | DOI: 10.32725/jab.2005.004

Biochemical and haematological differentiation of opiate addicts from healthy subjects. A case control study

José Fernando Díaz-Flores Estévez1, Felicitas Díaz-Flores Estévez2, Carlos Hernández Calzadilla2, Elena María Rodríguez Rodríguez3, Carlos Díaz Romero3,*, Lluis Serra-Majem4
1 Laboratory of Clinical Analysis of the Drug Rehabilitation Center, Youth Association Cooperation "San Miguel", Santa Cruz de Tenerife, Spain
2 Central Laboratory, University Hospital of the Canary Islands, Santa Cruz de Tenerife, Spain
3 Department of Analytical Chemistry, Nutrition and Food Science. University of La Laguna, Santa Cruz de Tenerife, Spain
4 Department of Clinical Sciences. University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain

The biochemical and haematological parameters of nutritional interest were determined in the serum of opiate addicts in order to compare them with those obtained in healthy subjects. The blood of 106 opiate addicts in detoxification treatment (n=19) or in Methadone Maintenance Treatment Program (MMTP) (n=87) was studied. Opiate addicts presented lower levels in the number of red cells, cholesterol, albumin, retinol, α-tocopherol, folic acid, K and Se and higher levels in the number of leukocytes, GOT, GPT and Na, than the control group. The opiate addicts in MMTP had higher levels of glucose, triglycerides, Mg and P than the opiate addicts in the detoxification treatment and control groups. Significant correlations between the three vitamins (folic acid, retinal and α-tocopherol) were observed and the graphic representations suggest a biochemical differentiation between opiate addicts and healthy subjects. Factor analysis made it possible to select seven factors explaining 66.2% of the total variance, and representing the first and fourth factor, opiate addicts tended to separate from the control group.

Keywords: opiate addicts; correlation and factor analysis; detoxification; methadone

Received: January 12, 2005; Revised: January 21, 2005; Published: March 31, 2005  Show citation

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Díaz-Flores Estévez JF, Díaz-Flores Estévez F, Hernández Calzadilla C, Rodríguez Rodríguez EM, Romero CD, Serra-Majem L. Biochemical and haematological differentiation of opiate addicts from healthy subjects. A case control study. J Appl Biomed. 2005;3(1):37-46. doi: 10.32725/jab.2005.004.
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