J Appl Biomed 4:197-203, 2006 | DOI: 10.32725/jab.2006.022

Cytogenetic methods and biomonitoring of occupational exposure to genotoxic factors

Tomáš Adamus1,*, Irena Mikulenková2, Lubomír Dobiáš1,2, Jaroslava Havránková2, Tomáš Pek1
1 Faculty of Health and Social Studies, University of Ostrava, Department of Medical Examination Methods and Medical Biology, Ostrava, Czech Republic
2 Institute of Public Health Ostrava, Department of Genetic Toxicology, Ostrava , Czech Republic

The professional aim of this project was to map the detection of genotoxicants using cytogenetic methods. It summarizes the results of four studies carried out at three different workplaces in different industries. The main aim of the study was also to monitor types of exposure to genotoxicants and their impact on the human population: The exposure of blast furnace workers in the steel industry to genotoxic factors; the exposure of coke oven plant workers to genotoxic factors, and the exposure to genotoxic factors in workplaces in the chemical industry - in particular to heavy metals (Ni, Cd). Cytogenetic analysis and the micronucleus test are sensitive methods in the field of biomonitoring of human exposure in industry, and play an important role in the prevention of damage to human health.

Keywords: genotoxicants; micronucleus test; binucleated cells; furnace workers

Received: June 20, 2006; Revised: September 11, 2006; Published: July 31, 2006  Show citation

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Adamus T, Mikulenková I, Dobiáš L, Havránková J, Pek T. Cytogenetic methods and biomonitoring of occupational exposure to genotoxic factors. J Appl Biomed. 2006;4(4):197-203. doi: 10.32725/jab.2006.022.
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