J Appl Biomed 8:19-22, 2010 | DOI: 10.2478/v10136-009-0003-y

Alternative haematotoxicological testing

Josef Berger*
Faculty of Health and Social Studies, University of South Bohemia in České Budějovice, Czech Republic

Standard haematological procedures in preclinical subchronic and chronic toxicity studies are carried out on dogs, rats and other mammals. In vitro clonic assays CFU-GM, BFU-E, CFU-E, CFU-Mgkr and pluripotent stem cells are used in screening candidate compounds to predict acute cytopenias, but they are not able to reveal the risk of suppression which can develop after repeated administration. No in silico studies have yet been published in haematotoxicology. More recent haematotoxicological in vivo models represent invertebrates: they can be used in both ecotoxicology and in the screening of myelotoxicity.

Keywords: myelotoxicity; alternative testing; in vitro; in silico; invetebrate

Received: October 16, 2009; Revised: November 22, 2009; Published: March 31, 2010  Show citation

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Berger J. Alternative haematotoxicological testing. J Appl Biomed. 2010;8(1):19-22. doi: 10.2478/v10136-009-0003-y.
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