J Appl Biomed 12:17-23, 2014 | DOI: 10.1016/j.jab.2013.03.001

Fate of two types of cerebellar graft in wild type and cerebellar mutant mice

Miroslava Čedíkováa,b, Zbyněk Houdekc,d, Václav Babuškae, Vlastimil Kuldae, František Vožehb,c, Nicolas Zechf, Lenka Černág, Kristýna Krakorovág, Milena Králíčkováa,b,*, Jan Cendelínb,c
a Department of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University in Prague, Plzeň, Czech Republic
b Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, Plzeň, Czech Republic
c Department of Pathophysiology, Faculty of Medicine in Pilsen, Charles University in Prague, Plzeň, Czech Republic
d Centre of Biology, Geosciences and Environmental Education, Faculty of Education, University of West Bohemia in Plzen, Plzeň, Czech Republic
e Department of Medical Chemistry and Biochemistry, Faculty of Medicine in Pilsen, Charles University in Prague, Plzeň, Czech Republic
f IVF Centers Prof. Zech - Pilsen, Plzeň, Czech Republic
g Department of Neurology, Faculty of Medicine in Pilsen, Charles University in Prague, Plzeň, Czech Republic

The possibility of regeneration in a damaged central nervous system (CNS) is limited and therapy of CNS diseases accompanied with neuronal loss is problematic.
Lurcher (Lc) mutant mice represent a model for olivocerebellar degeneration.
Heterozygotes suffer from a complete loss of cerebellar Purkinje cells and a secondary reduction of granule cells and inferior olive neuron number.

Keywords: P19-derived neuroprogenitors; Naive P19 cells; Intracerebellar application; Graft survival

Received: January 13, 2013; Revised: March 16, 2013; Accepted: March 16, 2013; Published: January 1, 2014  Show citation

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Čedíková M, Houdek Z, Babuška V, Kulda V, Vožeh F, Zech N, et al.. Fate of two types of cerebellar graft in wild type and cerebellar mutant mice. J Appl Biomed. 2014;12(1):17-23. doi: 10.1016/j.jab.2013.03.001.
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