J Appl Biomed 13:39-46, 2015 | DOI: 10.1016/j.jab.2014.10.001

Neuroprotective efficacy of newly developed oximes in comparison with currently available oximes in tabun-poisoned rats

Jiri Kassa^*, Jan Misik, Jana Zdarova Karasova

Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defense, Hradec Kralove, Czech Republic

The ability of two newly developed oximes (K361, K378) to reduce tabun-induced acute neurotoxic signs and symptoms was compared with the oxime K203 and trimedoxime using a functional observational battery. The neuroprotective effects of the oximes studied combined with atropine on rats poisoned with tabun at a sublethal dose (310 μg/kg i.m.; 90% of LD₅₀ value) were evaluated. Tabun-induced neurotoxicity was monitored by functional observational battery at 2 h following tabun challenge. The results indicate that all tested oximes combined with atropine enable tabun-poisoned rats to survive till the end of experiment. Both newly developed oximes (K361, K378) combined with atropine were able to decrease tabun-induced neurotoxicity in the case of sublethal poisonings although they did not eliminate all tabun-induced acute neurotoxic signs and symptoms. Their ability to decrease tabun-induced acute neurotoxicity was slightly lower than that of trimedoxime and the oxime K203. Therefore, the newly developed oximes are not suitable for the replacement of commonly used oximes (especially trimedoxime and obidoxime) in the treatment of acute tabun poisonings.

Keywords: Tabun; Neurotoxicity; Functional observational battery; Oximes; Rats

Received: August 10, 2014; Revised: October 9, 2014; Accepted: October 10, 2014; Published: February 1, 2015  Show citation