Journal of Applied Biomedicine, 2010 (vol. 8), issue 4

Index of Authors

J Appl Biomed 8:iii-iv, 2010 | DOI: 10.1016/S1214-021X(14)60099-5

Subject Index

J Appl Biomed 8:v-vi, 2010 | DOI: 10.1016/S1214-021X(14)60100-9

Assessing variability in neonatal blood pressure, notably in hypotension

Germaine Cornélissen, Franz Halberg, Elena Vasilievna Syutkina, Galina Victorovna Yatsyk, Anatoly Victorovich Masalov, Othild Schwartzkopff, Dana Johnson

J Appl Biomed 8:209-211, 2010 | DOI: 10.2478/v10136-009-0029-1  

New reports corroborate our prior finding that hypotension in infancy is associated with impaired neurodevelopment later in childhood. We had also found that neurological deficit is further associated with a more pronounced circadian variation in transcutaneous pO₂ (tcpO₂). New evidence in adulthood prompts the recommendation to automatically monitor vital signs for continued surveillance, relying on the methods of chronobiology for data analysis as-one-goes. This applies notably early in extra-uterine life when infants may be particularly sensitive to ischemic cerebral injury secondary to systemic hypotension. Monitoring at this...

Chronobiologic study of the GH-IGF1 axis and the ageing immune system

Gianluigi Mazzoccoli, Francesco Giuliani, Michele Inglese, Nunzia Marzulli, Mariangela Pia Dagostino, Angelo De Cata, Antonio Greco, Stefano Carughi, Roberto Tarquini

J Appl Biomed 8:213-226, 2010 | DOI: 10.2478/v10136-009-0028-2  

One of the many systems that weakens as we age is our immune system and there is a reduction in the GH-IGF1 axis activity with increasing age. In this study we evaluated the immune system and the GH-IGF1 axis function in healthy ageing. CD3, CD4, CD20, CD25, HLA-DR and GH showed acrophase during the night, whereas CD8, CD16 and TCRγδ expressing cells showed acrophase during the day. MESOR of CD3 was higher in the old aged subjects, MESOR of CD20 and CD20 values at 14:00h and at 02:00h were higher in the young middle aged subjects, MESOR of CD25 and CD25 values at 10:00 were higher in the elderly subjects, MESOR of HLA-DR was higher in the...

Bacterial toxin-antitoxin systems targeting translation

Ramón Díaz-Orejas, Elizabeth Diago-Navarro, Ana María Hernández Arriaga, Juan López-Villarejo, Marc Lemonnier, Inma Moreno-Córdoba, Concha Nieto, Manuel Espinosa

J Appl Biomed 8:179-188, 2010 | DOI: 10.2478/v10136-009-0021-9  

Toxin-antitoxin systems (TAS) emerged more than 25 years ago and have since developed as an important field in molecular microbiology. TAS are autoregulated operons coding a stable toxin and an unstable antitoxin found in the plasmids and chromosomes of Bacteria and Archaea. The conditional activation of their toxins interferes with cell growth/viability and, depending on the context, can influence plasmid maintenance, stress management, bacterial persistence, cell differentiation and, it is likely also bacterial virulence. This review summarizes recent results on the parD system of plasmid R1 and on the chromosomal relBE systems found...

Temperature-perception, molecules and mechanisms

Rafael Catalá, Julio Salinas

J Appl Biomed 8:189-198, 2010 | DOI: 10.2478/v10136-009-0026-4  

The strategies used by living organisms to survive under low and freezing temperatures reveal the extraordinary adaptability of life on Earth. Understanding the molecular mechanisms underlying cold adaptation and freezing survival will provide new insights into the existing relationships between living organisms and their environment, and the possibility of developing multiple biotechnological applications. In the case of plants, the use of classical genetic and new "omics" approaches is allowing to the identification of new elements involved in regulating the cold acclimation response. The challenge ahead is to determine temperature-perception molecules...

Arsenic trioxide as an anti-tumour agent: mechanisms of action and strategies of sensitization

Yolanda Sánchez, Donna Amrán, Elena de Blas, Patricio Aller

J Appl Biomed 8:199-208, 2010 | DOI: 10.2478/v10136-009-0027-3  

Arsenic trioxide (As₂O₃, ATO) is a very efficacious, clinically established agent for the treatment of acute promyelocytic leukaemia, and also potentially useful against other haematological and non-haematological malignancies. Nonetheless, the relative resistance of many tumour cell types requires the generation of sensitizing strategies. One of the properties of ATO which might be exploited for therapeutic purposes is its sensitivity to the intracellular oxidant state, as revealed by increased apoptosis production under conditions of reduced glutathione (GSH) depletion and/or elevated reactive oxygen species (ROS) content. This...

The Centro de Investigaciones Biológicas (Center for Biological Research) in Madrid, Spain: 50 years of excellent fundamental multidisciplinary biological research

Francisco Javier Medina

J Appl Biomed 8:227, 2010 | DOI: 10.1016/S1214-021X(14)60096-X  

In memoriam Prof. Dr. Peter Roland

Alfred Goldschmid

J Appl Biomed 8:228, 2010 | DOI: 10.1016/S1214-021X(14)60097-1  

80^th birthday of Professor Karel Smetana

Roman Janisch

J Appl Biomed 8:229, 2010 | DOI: 10.1016/S1214-021X(14)60098-3