Journal of Applied Biomedicine, 2022 (vol. 20), issue 3
Original Research Article
Effects of 17-β-estradiol released from shape-memory terpolymer rods on sciatic nerve regeneration after injury and repair with chitosan nerve conduit in female rats
Edyta Olakowska, Adam Właszczuk, Artur Turek, Aleksandra Borecka, Arkadiusz Li¶kiewicz, Dariusz Wawro, Janusz Kasperczyk, Halina Jędrzejowska-Szypułka
J Appl Biomed 20:87-97, 2022 | DOI: 10.32725/jab.2022.010 
The aim of this study was to assess 17-β-estradiol (E2) influence on sciatic nerve regeneration after injury followed by a repair with chitosan conduit in ovariectomized female rats. The study was performed in 2 groups (n = 16) of rats: OVChit - after excision of a fragment of the sciatic nerve, a chitosan conduit was implanted; OVChitE10 group - additionally to chitosan conduit, shape-memory terpolymer rods based on poly(L-lactide-co-glycolide- co-trimethylene carbonate) releasing 17-β-estradiol for 20 weeks were implanted. The mean number of regenerating axons and mean fiber area were significantly greater in 17-β-estradiol-treated...
Photodynamic therapy in breast cancer treatment
Joanna Gustalik, David Aebisher, Dorota Bartusik-Aebisher
J Appl Biomed 20:98-105, 2022 | DOI: 10.32725/jab.2022.013
Breast cancer is a serious public problem in modern society. Photodynamic therapy (PDT) is increasingly used in modern medicine. Currently, PDT is an innovative method of treating breast cancer. Irreversible damage to neoplastic tissues is associated with the use of physicochemical processes. Generating cytotoxic reactive oxygen species [singlet oxygen (1O2)] is leading to tumor cell death. At the same time, valuable information can be extracted from breast cancer cells. Photogenerated 1O2 is the major factor responsible for cell necrosis during PDT. 1O2 can react rapidly intracellularly with all organic substances. The use of photodynamic therapy...
Genetic variation in the ADIPOQ gene and serum adiponectin increase the risk of bladder cancer
Lina Elsalem, Mahmoud A. Alfaqih, Samir Al Bashir, Omar Halalsheh, Haneen A. Basheer, Khawla Mhedat, Yousef Khader, Klaus Pors
J Appl Biomed 20:106-113, 2022 | DOI: 10.32725/jab.2022.012
Bladder cancer (BC) is the 10th most common cancer worldwide. Genetic studies estimated 30% heritability in BC risk. Adiponectin is an adipocytokine that has important roles in the regulation of energy metabolism. Recent evidence suggests dysregulation of adiponectin levels in BC tissues. Serum level of adiponectin is influenced by single nucleotide polymorphisms (SNPs) in the ADIPOQ gene. However, limited evidence is available regarding the association between adiponectin serum levels or SNPs in ADIPOQ and BC risk. This study aimed to assess whether adiponectin serum levels or SNPs in ADIPOQ may modify BC risk. In this case-control...
Case Report
SARS-CoV-2 vaccination associated venous sinus thrombosis in three patients
Josef Finsterer
J Appl Biomed 20:83-86, 2022 | DOI: 10.32725/jab.2022.011
Introduction: There is increasing evidence that vaccinations against the severe acquired respiratory syndrome coronavirus type-2 (SARS-CoV-2) virus can be followed by venous sinus thrombosis (VST). Here we report on three patients who developed VST shortly after SARS-CoV-2 vaccinations. Case series: An 80-year-old male, a 58-year-old male, and a 34-year-old female developed VST 14 to 24 days after the first dose of an mRNA-based SARS-CoV-2 vaccine. All three patients profited from analgesics, heparinisation, and oral anticoagulation, but made only an incomplete recovery at the time of discharge. Arguments for a causal relationship are: VST was time-linked...