Journal of Applied Biomedicine, 2026 (vol. 24), issue 3
Original Research Article
Genetic polymorphisms in the SLC27A5 gene are associated with biochemical characteristics of HBV patients in Yunnan
Chaoqi Zhu, Qingyuan Wei, Yue Feng, Xueshan Xia, A-Mei Zhang *
J Appl Biomed 24:93-100, 2026 | DOI: 10.32725/jab.2026.008 
Background: Lipid droplets could influence hepatitis B virus (HBV) replication and release, as well as disease progression in patients with chronic HBV. The solute carrier family 27 member 5 (SLC27A5) gene is highly expressed in the liver and possessed bile acid-CoA ligase activity. However, no previous study has investigated the role of the SLC27A5 gene in HBV infection or disease progression. Methods: A total of 400 chronic HBV patients and 300 controls were collected in Yunnan Province to genotype three single nucleotide polymorphisms (SNPs) of the SLC27A5 gene and investigate potential association between SNPs and HBV infection...