J Appl Biomed 5:13-17, 2007 | DOI: 10.32725/jab.2007.002

Convenient synthesis of 3,5-dialkoxy-4-hydroxy cinnamic acids

Young-Sik Jung^*, Hyang-Ok Jo

Medicinal Science Division, Korea Research Institute of Chemical Technology, Yusong, Daejeon, Korea

3,5-Dialkoxy-4-hydroxy cinnamic acids

8a-g have been conveniently synthesized from methyl 4-benzyloxy-3,5-dihydroxybenzoate

4. In five steps, cinamic acids

8a-g having various alkoxy groups on C-3 and C-5 positions of the phenyl ring were obtained in 33-70 % overall yields. The antioxidant properties of the newly synthesized amides and the effects on lipid peroxidation in rat brain homogenate will be examined by thiobarbituric acid reactive substances (TBARS) assay and other methods.

Keywords: 3,5-dialkoxy-4-hydroxy cinnamic acids; dialkylation; lipid peroxidation

Received: October 25, 2006; Revised: November 10, 2006; Published: March 31, 2007  Show citation