J Appl Biomed 2:195-198, 2004 | DOI: 10.32725/jab.2004.023

A general method for the quaternization of N,N-dimethyl benzylamines with long chain n-alkylbromides

Kamil Kuča1,*, Milan Kivala2, Vlastimil Dohnal3
1 Department of Toxicology, Purkyně Medical Military Academy, Hradec Králové, Czech Republic
2 Department of Organic Chemistry, Institute of Chemical Technology, Praha, Czech Republic
3 Department of Analytic Chemistry, Faculty of Science, Masaryk University, Brno, Czech Republic

Benzalkonium bromides (BAK) are an important class of cationic surfactants with both industrial and commercial uses. They are used as preservatives for ophthalmic, nasal and parenteral products and they are also used as a topical antiseptic and medical equipment disinfectant. In this work a universal method for the preparation of these compounds is described. Using quaternization of N,N-dimethylbenzylamines with long-chain n-alkylbromides we have prepared C8, C10, C12, C14, C16, C18 and C20 homologues of the benzalkonium bromides (BAK).

Keywords: benzalkonium bromides; dimethylbenzylamines; n-alkylbromides; alkylating agent; quaternization

Received: August 12, 2004; Revised: October 5, 2004; Published: July 31, 2004  Show citation

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Kuča K, Kivala M, Dohnal V. A general method for the quaternization of N,N-dimethyl benzylamines with long chain n-alkylbromides. J Appl Biomed. 2004;2(4):195-198. doi: 10.32725/jab.2004.023.
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