Journal of Applied Biomedicine, 2004 (vol. 2), issue 4
Original Research Article
A general method for the quaternization of N,N-dimethyl benzylamines with long chain n-alkylbromides
Kamil Kuča, Milan Kivala, Vlastimil Dohnal
J Appl Biomed 2:195-198, 2004 | DOI: 10.32725/jab.2004.023 
Benzalkonium bromides (BAK) are an important class of cationic surfactants with both industrial and commercial uses. They are used as preservatives for ophthalmic, nasal and parenteral products and they are also used as a topical antiseptic and medical equipment disinfectant. In this work a universal method for the preparation of these compounds is described. Using quaternization of N,N-dimethylbenzylamines with long-chain n-alkylbromides we have prepared C8, C10, C12, C14, C16, C18 and C20 homologues of the benzalkonium bromides (BAK).
Circadian phagocytic activity of neutrophils and its modulation by light
Monica L. Hriscu
J Appl Biomed 2:199-211, 2004 | DOI: 10.32725/jab.2004.024
The experimental data reviewed herein is aimed at an evaluation of the circadian dynamics of neutrophil phagocytosis (basal phagocytosis, phagocytic response, and adherence) in mice and rats and attempts to establish whether the functional pinealectomy accomplished through constant light exposure affects the level and/or circadian oscillation of the parameters. In both species, basal phagocytic activity appears as a periodic function, peaking in the second half of the night (03:00-04:00). Adherence to nylon fibres displays a circadian oscillation with two maxima (10:00 and 22:00). Under constant light, the mean phagocytic activity is lowered by 40%,...
Reviews
Chronohaematology
Josef Berger
J Appl Biomed 2:179-185, 2004 | DOI: 10.32725/jab.2004.021
Rhythmic changes in a number of haematological characteristics have been described in many published papers during the 20th and at the beginning of the 21st century. The best known are circadian rhythms, which are mostly correlated with the light/dark regime, inducing rhythmic changes in levels of melatonin, synchronised by a suprachiasmatic nucleus and the retinohypothalamic input. These circadian rhythms in men and diurnal animals have an inverse relationship to rhythms in nocturnal beings. Some haematological rhythms are modified by other synchronisers. Knowledge of circadian rhythms in haematological characteristics is important...
Recessive disorders - a serious health hazard?
Jindřich Čítek, Barbora Bláhová
J Appl Biomed 2:187-194, 2004 | DOI: 10.32725/jab.2004.022
The aim of this study is to summarize new findings on the most important recessive hereditary disorders in cattle. Important diseases in cattle breeding are: BLAD (Bovine Leukocyte Adhesion Deficiency), DUMPS (Deficiency of Uridine - 5-Monophosphate Synthase), MSUD (Maple Syrup Urine Disease), Bovine Citrullinaemia, and - not detected until 2000 - CVM (Complex Vertebral Malformation). Some of these disorders occur also in man. Thanks to the intensive exploitation of elite sires in artificial insemination, the risk of a fast spread world-wide of recessive hereditary defects is extremely high. In animals there are methods for the detection of heterozygotes...