J Appl Biomed 3:83-90, 2005 | DOI: 10.32725/jab.2005.010

Synthesis and activity of 4-(2',4'-difluorobiphenylyl)-2-methylbutyric acid (deoxoflobufen) and its derivatives

Petr Bulej1, Miroslav Kuchař2, Vladimíra Panajotova3, Alexandr Jegorov4,*
1 IVAX Pharmaceuticals, Opava, Czech Republic
2 Zentiva-VÚFB a.s., Praha 10, Czech Republic
3 RE&D VÚFB s.r.o., Praha 9, Czech Republic
4 IVAX Pharmaceuticals, Research Unit, České Budějovice, Czech Republic

The series of 4-(2',4'-difluorobiphenylyl)-2-methylbutyric acid (deoxoflobufen,

1) and its four amides and two salts were prepared and tested for anti-inflammatory activity in rats and mice, using as models carrageenan-induced paw oedema, pleuritis, and arachidonic acid-induced ear inflammation, and on leucotriene B4 production in cells.

Keywords: deoxoflobufen; derivatives; salts; anti-inflammatory activity

Received: January 3, 2005; Revised: February 7, 2005; Published: July 31, 2005  Show citation

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Bulej P, Kuchař M, Panajotova V, Jegorov A. Synthesis and activity of 4-(2',4'-difluorobiphenylyl)-2-methylbutyric acid (deoxoflobufen) and its derivatives. J Appl Biomed. 2005;3(2):83-90. doi: 10.32725/jab.2005.010.
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