J Appl Biomed 4:73-86, 2006 | DOI: 10.32725/jab.2006.007

Chronobiology's progress. Part II, chronomics for an immediately applicable biomedicine

Franz Halberg^1,*, Germaine Cornélissen¹, George Katinas¹, Levan Tvildiani², Marina Gigolashvili³, Ketevan Janashia⁴, Tim Toba¹, Miguel Revilla⁵, Philip Regal¹, Robert B. Sothern¹, Hans W. Wendt¹, Zhengrong Wang⁶, Michal Zeman⁷, Rita Jozsa⁸, R.B. Singh⁹, Gen Mitsutake¹⁰, Sergei M. Chibisov¹¹, Jong Lee¹, Dan Holley¹², James E. Holte¹, Robert P. Sonkowsky¹, Othild Schwartzkopff¹, Patrick Delmore¹³, Kuniaki Otsuka¹⁰, Earl E. Bakken¹⁴, Jerzy Czaplicki¹⁵, the International BIOCOS Group

¹ Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN, USA

² Department of Internal Medicine, Tbilisi State Medical University, Tbilisi, Georgia

³ Georgian National Astrophysical Observatory, Tbilisi, Georgia

⁴ Ministry of Labour, Health and Social Affairs of Georgia, Tbilisi, Georgia

⁵ University of Valladolid, Spain

⁶ Sichuan University, Chengdu, Sichuan, China

⁷ Department of Animal Physiology, Comenius University, Bratislava, Slovakia

⁸ University Pecs, Pecs, Hungary

⁹ Nutrition and Heart Centre, Halberg Hospital & Research Institute, Moradabad, India

¹⁰ Tokyo Women's Medical University, Medical Center East, Tokyo, Japan

¹¹ People's Friendship University of Russia, Moscow, Russia

¹² San Jose State University, San Jose, CA, USA

¹³ Medtronic Inc., Fridley, MN, USA

¹⁴ North Hawaii Community Hospital Inc., Kamuela, HI, USA

¹⁵ Institute of Pharmacology and Structural Biology, CNRS, Paul Sabatier University, Toulouse, France

Chronomic cardiovascular surveillance serves to recognise and treat any risk elevation as well as overt disease, and to ascertain whether treatment is effective and, if so, for how long treatment effects lasts, be it for lowering an increased risk and/or in surveilling the success or failure of treatment. A treatment-associated increase in circadian amplitude of blood pressure (BP) may induce iatrogenic overswinging, also dubbed CHAT (

circadian

hyper-

amplitude-

tension), in some patients, thereby increasing cardiovascular disease risk unknowingly to care provider and receiver.

Keywords: chronobioethics; food restriction; blood pressure surveillance; CHAT; health care

Received: December 22, 2005; Revised: February 21, 2006; Published: July 31, 2006  Show citation