J Appl Biomed 4:87-94, 2006 | DOI: 10.32725/jab.2006.008

GOSA, a simulated annealing-based program for global optimization of nonlinear problems, also reveals transyears

Jerzy Czaplicki1,*, Germaine Cornélissen2, Franz Halberg2
1 Institute of Pharmacology and Structural Biology, CNRS UMR 5089, Toulouse, France
2 Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN, USA

Transyears in biology have been documented thus far by the extended cosinor approach, including linear-nonlinear rhythmometry. We here confirm the existence of transyears by simulated annealing, a method originally developed for a much broader use, but described and introduced herein for validating its application to time series. The method is illustrated both on an artificial test case with known components and on biological data. We provide a table comparing results by the two methods and trust that the procedure will serve the budding sciences of chronobiology (the study of mechanisms underlying biological time structure), chronomics (the mapping of time structures in and around us), and chronobioethics, using the foregoing disciplines to add to concern for illnesses of individuals also a budding focus on diseases of societies, like crime, and of nations and civilizations, like war.

Keywords: simulated annealing; linear-nonlinear rhythmometry; transyears; cosinor

Received: January 12, 2006; Revised: March 14, 2006; Published: July 31, 2006  Show citation

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Czaplicki J, Cornélissen G, Halberg F. GOSA, a simulated annealing-based program for global optimization of nonlinear problems, also reveals transyears. J Appl Biomed. 2006;4(2):87-94. doi: 10.32725/jab.2006.008.
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