J Appl Biomed 5:97-104, 2007 | DOI: 10.32725/jab.2007.014

Antihyperglycaemic and antiperoxidative effect of Helicteres isora L. bark extracts in streptozotocin-induced diabetic rats

Ganesan Kumar^1,*, Gani Sharmila Banu², Arunachalam Ganesan Murugesan¹, Moses Rajasekara Pandian²

¹ Manonmaniam Sundaranar University, Sri Paramakalyani Centre for Environmental Sciences, Alwarkurichi, Tamilnadu, India 627412

² Centre for Biotechnology, Muthayammal College of Arts and Sciences, Kakkaveri, Rasipuram, Namakkal, Tamilnadu, India 637408

The present investigation shows the antihyperglycaemic activity of aqueous extract of bark of Helicteres isora L. (100, 200 mg/kg b.w./p.o.) in streptozotocin (STZ) induced diabetic rats. Blood glucose levels, body weight, food and liquid intake were measured on every 5^th day over a period of 14 days. A single injection of STZ at a dose of 60 mg/kg b.w./i.p. elevated the glucose levels >240mg/dl after 5 days. Administration of H. isora at a dose of 100, 200 mg/kg/p.o. resulted in a significant (p

Keywords: Helicteres isora; streptozotocin; antihyperglycaemic activity; antioxidant potential

Received: December 21, 2006; Revised: January 22, 2007; Published: July 31, 2007  Show citation