J Appl Biomed 7:75-91, 2009 | DOI: 10.32725/jab.2009.008

Gold and nano-gold in medicine: overview, toxicology and perspectives

Nagender Reddy Panyala¹, Eladia María Peña-Méndez², Josef Havel^1,3,*

¹ Department of Chemistry, Faculty of Science, Masaryk University, Brno, Czech Republic

² Department of Analytical Chemistry, Nutrition and Food Chemistry, Faculty of Chemistry, University of La Laguna, La Laguna, Tenerife, Spain

³ Department of Physical Electronics, Faculty of Science, Masaryk University, Brno, Czech Republic

Nano-technology has entered the field of medicine in recent decades and many of the nanomaterials developed have already had a high impact on health care. Among nanomaterials, gold nanoparticles (GNPs) and gold quantum dots (QDs) are receiving significant attention because their unique physical, chemical and biological properties are quite different from the bulk of their counterparts. In this article, after a brief historical overview, the use of gold and nano-gold in medicine is reviewed, analyzed, and discussed. The review particularly deals with the use of GNPs and bio-conjugated GNPs in cancer treatment, drug or gene delivery, DNA detection, biomedical imaging including that of brain activity, enhancement of gene regulation, the detection of toxic metals, immuno-assays, disease detection and diagnostics, therapy and also the toxicity of gold and GNPs, etc. A number of novel applications of GNPs in medicine and perspectives of nano-gold use in medicine are also discussed.

Keywords: gold nanoparticles; gold quantum dots; nanomedicine; biomolecules; toxicity

Received: March 21, 2009; Revised: May 23, 2009; Published: July 31, 2009  Show citation