J Appl Biomed 7:101-109, 2009 | DOI: 10.32725/jab.2009.010

Glutathione, glutathione-dependent enzymes and antioxidant status in gastric carcinoma patients

Palanisamy Pasupathi1,*, Ganesan Saravanan2, Palanisamy Chinnaswamy3, Govindaswamy Bakthavathsalam1
1 Institute of Laboratory Medicine, K. G. Hospital and Post Graduate Medical Institute, Tamil Nadu, India
2 Institute of Laboratory Medicine, Kovai Medical Center and Hospital (KMCH), Tamil Nadu, India
3 Department of Biochemistry & Biotechnology, Faculty of Science, Annamalai University, Tamil Nadu, India

Oxidative stress plays an important role in malignant transformation and is postulated to be associated with increased lipid peroxidation. The aim of this study was to determine the extent of lipid peroxidation with the antioxidant status in patients with gastric cancer. The study population consisted of fifty newly diagnosed gastric cancer patients and an equal number of age- and sex-matched healthy control subjects. Lipid peroxidation as evidenced by thiobarbutric acid reactive substances (TBARS), and also the status of enzymatic (superoxide dismutase - SOD, catalase - CAT, glutathione peroxidase - GPx, glutathione reductase - GR, glutathione S-transferase - GST) and non-enzymatic (reduced glutathione - GSH) antioxidants, were determined. Enhanced lipid peroxidation with concomitant depletion of antioxidants was observed in gastric cancer patients as compared to healthy control subjects. The present study highlights the occurrence of lipid peroxidation and possible breakdown of antioxidant status in patients with gastric carcinoma.

Keywords: gastric cancer; lipid peroxidation; antioxidants; glutathione; GSH-dependent enzymes

Received: September 24, 2008; Revised: January 5, 2009; Published: July 31, 2009  Show citation

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Pasupathi P, Saravanan G, Chinnaswamy P, Bakthavathsalam G. Glutathione, glutathione-dependent enzymes and antioxidant status in gastric carcinoma patients. J Appl Biomed. 2009;7(2):101-109. doi: 10.32725/jab.2009.010.
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